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Bromodomain inhibitors and cancer therapy: From structures to applications
Aberrations in the epigenetic landscape are a hallmark of cancer. Alterations in enzymes that are “writers,” “erasers,” or “readers” of histone modification marks are common. Bromodomains are “readers” that bind acetylated lysines in histone tails. Their most important function is the regulation of...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Taylor & Francis
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5453193/ https://www.ncbi.nlm.nih.gov/pubmed/27911230 http://dx.doi.org/10.1080/15592294.2016.1265710 |