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In vitro evaluation of a new iterative reconstruction algorithm for dose reduction in coronary artery calcium scoring

BACKGROUND: Coronary artery calcium (CAC) scoring is a widespread tool for cardiac risk assessment in asymptomatic patients and accompanying possible adverse effects, i.e. radiation exposure, should be as low as reasonably achievable. PURPOSE: To evaluate a new iterative reconstruction (IR) algorith...

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Autores principales: Gassenmaier, Tobias, Allmendinger, Thomas, Kunz, Andreas S, Veyhl-Wichmann, Maike, Ergün, Süleyman, Bley, Thorsten A, Petritsch, Bernhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5453409/
https://www.ncbi.nlm.nih.gov/pubmed/28607763
http://dx.doi.org/10.1177/2058460117710682
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author Gassenmaier, Tobias
Allmendinger, Thomas
Kunz, Andreas S
Veyhl-Wichmann, Maike
Ergün, Süleyman
Bley, Thorsten A
Petritsch, Bernhard
author_facet Gassenmaier, Tobias
Allmendinger, Thomas
Kunz, Andreas S
Veyhl-Wichmann, Maike
Ergün, Süleyman
Bley, Thorsten A
Petritsch, Bernhard
author_sort Gassenmaier, Tobias
collection PubMed
description BACKGROUND: Coronary artery calcium (CAC) scoring is a widespread tool for cardiac risk assessment in asymptomatic patients and accompanying possible adverse effects, i.e. radiation exposure, should be as low as reasonably achievable. PURPOSE: To evaluate a new iterative reconstruction (IR) algorithm for dose reduction of in vitro coronary artery calcium scoring at different tube currents. MATERIAL AND METHODS: An anthropomorphic calcium scoring phantom was scanned in different configurations simulating slim, average-sized, and large patients. A standard calcium scoring protocol was performed on a third-generation dual-source CT at 120 kVp tube voltage. Reference tube current was 80 mAs as standard and stepwise reduced to 60, 40, 20, and 10 mAs. Images were reconstructed with weighted filtered back projection (wFBP) and a new version of an established IR kernel at different strength levels. Calcifications were quantified calculating Agatston and volume scores. Subjective image quality was visualized with scans of an ex vivo human heart. RESULTS: In general, Agatston and volume scores remained relatively stable between 80 and 40 mAs and increased at lower tube currents, particularly in the medium and large phantom. IR reduced this effect, as both Agatston and volume scores decreased with increasing levels of IR compared to wFBP (P < 0.001). Depending on selected parameters, radiation dose could be lowered by up to 86% in the large size phantom when selecting a reference tube current of 10 mAs with resulting Agatston levels close to the reference settings. CONCLUSION: New iterative reconstruction kernels may allow for reduction in tube current for established Agatston scoring protocols and consequently for substantial reduction in radiation exposure.
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spelling pubmed-54534092017-06-12 In vitro evaluation of a new iterative reconstruction algorithm for dose reduction in coronary artery calcium scoring Gassenmaier, Tobias Allmendinger, Thomas Kunz, Andreas S Veyhl-Wichmann, Maike Ergün, Süleyman Bley, Thorsten A Petritsch, Bernhard Acta Radiol Open Research BACKGROUND: Coronary artery calcium (CAC) scoring is a widespread tool for cardiac risk assessment in asymptomatic patients and accompanying possible adverse effects, i.e. radiation exposure, should be as low as reasonably achievable. PURPOSE: To evaluate a new iterative reconstruction (IR) algorithm for dose reduction of in vitro coronary artery calcium scoring at different tube currents. MATERIAL AND METHODS: An anthropomorphic calcium scoring phantom was scanned in different configurations simulating slim, average-sized, and large patients. A standard calcium scoring protocol was performed on a third-generation dual-source CT at 120 kVp tube voltage. Reference tube current was 80 mAs as standard and stepwise reduced to 60, 40, 20, and 10 mAs. Images were reconstructed with weighted filtered back projection (wFBP) and a new version of an established IR kernel at different strength levels. Calcifications were quantified calculating Agatston and volume scores. Subjective image quality was visualized with scans of an ex vivo human heart. RESULTS: In general, Agatston and volume scores remained relatively stable between 80 and 40 mAs and increased at lower tube currents, particularly in the medium and large phantom. IR reduced this effect, as both Agatston and volume scores decreased with increasing levels of IR compared to wFBP (P < 0.001). Depending on selected parameters, radiation dose could be lowered by up to 86% in the large size phantom when selecting a reference tube current of 10 mAs with resulting Agatston levels close to the reference settings. CONCLUSION: New iterative reconstruction kernels may allow for reduction in tube current for established Agatston scoring protocols and consequently for substantial reduction in radiation exposure. SAGE Publications 2017-05-29 /pmc/articles/PMC5453409/ /pubmed/28607763 http://dx.doi.org/10.1177/2058460117710682 Text en © The Foundation Acta Radiologica 2017 http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Research
Gassenmaier, Tobias
Allmendinger, Thomas
Kunz, Andreas S
Veyhl-Wichmann, Maike
Ergün, Süleyman
Bley, Thorsten A
Petritsch, Bernhard
In vitro evaluation of a new iterative reconstruction algorithm for dose reduction in coronary artery calcium scoring
title In vitro evaluation of a new iterative reconstruction algorithm for dose reduction in coronary artery calcium scoring
title_full In vitro evaluation of a new iterative reconstruction algorithm for dose reduction in coronary artery calcium scoring
title_fullStr In vitro evaluation of a new iterative reconstruction algorithm for dose reduction in coronary artery calcium scoring
title_full_unstemmed In vitro evaluation of a new iterative reconstruction algorithm for dose reduction in coronary artery calcium scoring
title_short In vitro evaluation of a new iterative reconstruction algorithm for dose reduction in coronary artery calcium scoring
title_sort in vitro evaluation of a new iterative reconstruction algorithm for dose reduction in coronary artery calcium scoring
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5453409/
https://www.ncbi.nlm.nih.gov/pubmed/28607763
http://dx.doi.org/10.1177/2058460117710682
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