Effect of post-mortem delay on N-terminal huntingtin protein fragments in human control and Huntington disease brain lysates

Huntington disease is associated with elongation of a CAG repeat in the HTT gene that results in a mutant huntingtin protein. Several studies have implicated N-terminal huntingtin protein fragments in Huntington disease pathogenesis. Ideally, these fragments are studied in human brain tissue. Howeve...

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Detalles Bibliográficos
Autores principales: Schut, Menno H., Patassini, Stefano, Kim, Eric H., Bullock, Jocelyn, Waldvogel, Henry J., Faull, Richard L. M., Pepers, Barry A., den Dunnen, Johan T., van Ommen, Gert-Jan B., van Roon-Mom, Willeke M. C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5453542/
https://www.ncbi.nlm.nih.gov/pubmed/28570578
http://dx.doi.org/10.1371/journal.pone.0178556

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