Cargando…

Non-standard radiotherapy fractionations delay the time to malignant transformation of low-grade gliomas

Grade II gliomas are slowly growing primary brain tumors that affect mostly young patients. Cytotoxic therapies (radiotherapy and/or chemotherapy) are used initially only for patients having a bad prognosis. These therapies are planned following the “maximum dose in minimum time” principle, i. e. th...

Descripción completa

Detalles Bibliográficos
Autores principales: Henares-Molina, Araceli, Benzekry, Sebastien, Lara, Pedro C., García-Rojo, Marcial, Pérez-García, Víctor M., Martínez-González, Alicia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5453550/
https://www.ncbi.nlm.nih.gov/pubmed/28570587
http://dx.doi.org/10.1371/journal.pone.0178552
_version_ 1783240683222466560
author Henares-Molina, Araceli
Benzekry, Sebastien
Lara, Pedro C.
García-Rojo, Marcial
Pérez-García, Víctor M.
Martínez-González, Alicia
author_facet Henares-Molina, Araceli
Benzekry, Sebastien
Lara, Pedro C.
García-Rojo, Marcial
Pérez-García, Víctor M.
Martínez-González, Alicia
author_sort Henares-Molina, Araceli
collection PubMed
description Grade II gliomas are slowly growing primary brain tumors that affect mostly young patients. Cytotoxic therapies (radiotherapy and/or chemotherapy) are used initially only for patients having a bad prognosis. These therapies are planned following the “maximum dose in minimum time” principle, i. e. the same schedule used for high-grade brain tumors in spite of their very different behavior. These tumors transform after a variable time into high-grade gliomas, which significantly decreases the patient’s life expectancy. In this paper we study mathematical models describing the growth of grade II gliomas in response to radiotherapy. We find that protracted metronomic fractionations, i.e. therapeutical schedules enlarging the time interval between low-dose radiotherapy fractions, may lead to a better tumor control without an increase in toxicity. Other non-standard fractionations such as protracted or hypoprotracted schemes may also be beneficial. The potential survival improvement depends on the tumor’s proliferation rate and can be even of the order of years. A conservative metronomic scheme, still being a suboptimal treatment, delays the time to malignant progression by at least one year when compared to the standard scheme.
format Online
Article
Text
id pubmed-5453550
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-54535502017-06-12 Non-standard radiotherapy fractionations delay the time to malignant transformation of low-grade gliomas Henares-Molina, Araceli Benzekry, Sebastien Lara, Pedro C. García-Rojo, Marcial Pérez-García, Víctor M. Martínez-González, Alicia PLoS One Research Article Grade II gliomas are slowly growing primary brain tumors that affect mostly young patients. Cytotoxic therapies (radiotherapy and/or chemotherapy) are used initially only for patients having a bad prognosis. These therapies are planned following the “maximum dose in minimum time” principle, i. e. the same schedule used for high-grade brain tumors in spite of their very different behavior. These tumors transform after a variable time into high-grade gliomas, which significantly decreases the patient’s life expectancy. In this paper we study mathematical models describing the growth of grade II gliomas in response to radiotherapy. We find that protracted metronomic fractionations, i.e. therapeutical schedules enlarging the time interval between low-dose radiotherapy fractions, may lead to a better tumor control without an increase in toxicity. Other non-standard fractionations such as protracted or hypoprotracted schemes may also be beneficial. The potential survival improvement depends on the tumor’s proliferation rate and can be even of the order of years. A conservative metronomic scheme, still being a suboptimal treatment, delays the time to malignant progression by at least one year when compared to the standard scheme. Public Library of Science 2017-06-01 /pmc/articles/PMC5453550/ /pubmed/28570587 http://dx.doi.org/10.1371/journal.pone.0178552 Text en © 2017 Henares-Molina et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Henares-Molina, Araceli
Benzekry, Sebastien
Lara, Pedro C.
García-Rojo, Marcial
Pérez-García, Víctor M.
Martínez-González, Alicia
Non-standard radiotherapy fractionations delay the time to malignant transformation of low-grade gliomas
title Non-standard radiotherapy fractionations delay the time to malignant transformation of low-grade gliomas
title_full Non-standard radiotherapy fractionations delay the time to malignant transformation of low-grade gliomas
title_fullStr Non-standard radiotherapy fractionations delay the time to malignant transformation of low-grade gliomas
title_full_unstemmed Non-standard radiotherapy fractionations delay the time to malignant transformation of low-grade gliomas
title_short Non-standard radiotherapy fractionations delay the time to malignant transformation of low-grade gliomas
title_sort non-standard radiotherapy fractionations delay the time to malignant transformation of low-grade gliomas
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5453550/
https://www.ncbi.nlm.nih.gov/pubmed/28570587
http://dx.doi.org/10.1371/journal.pone.0178552
work_keys_str_mv AT henaresmolinaaraceli nonstandardradiotherapyfractionationsdelaythetimetomalignanttransformationoflowgradegliomas
AT benzekrysebastien nonstandardradiotherapyfractionationsdelaythetimetomalignanttransformationoflowgradegliomas
AT larapedroc nonstandardradiotherapyfractionationsdelaythetimetomalignanttransformationoflowgradegliomas
AT garciarojomarcial nonstandardradiotherapyfractionationsdelaythetimetomalignanttransformationoflowgradegliomas
AT perezgarciavictorm nonstandardradiotherapyfractionationsdelaythetimetomalignanttransformationoflowgradegliomas
AT martinezgonzalezalicia nonstandardradiotherapyfractionationsdelaythetimetomalignanttransformationoflowgradegliomas