Aryloxyalkanoic Acids as Non-Covalent Modifiers of the Allosteric Properties of Hemoglobin

Hemoglobin (Hb) modifiers that stereospecifically inhibit sickle hemoglobin polymer formation and/or allosterically increase Hb affinity for oxygen have been shown to prevent the primary pathophysiology of sickle cell disease (SCD), specifically, Hb polymerization and red blood cell sickling. Severa...

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Detalles Bibliográficos
Autores principales: Omar, Abdelsattar M., Mahran, Mona A., Ghatge, Mohini S., Bamane, Faida H. A., Ahmed, Mostafa H., El-Araby, Moustafa E., Abdulmalik, Osheiza, Safo, Martin K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5453642/
https://www.ncbi.nlm.nih.gov/pubmed/27529207
http://dx.doi.org/10.3390/molecules21081057

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5453642/
https://www.ncbi.nlm.nih.gov/pubmed/27529207
http://dx.doi.org/10.3390/molecules21081057

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