Metoprolol-induced Severe Liver Injury and Successful Management with Therapeutic Plasma Exchange

Liver injury caused by metoprolol is very rare with current reports limited to an isolated elevation in transaminases. We report the first case of severe icteric liver injury leading to hepatic encephalopathy secondary to metoprolol use in a patient diagnosed with coronary heart disease. We also des...

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Detalles Bibliográficos
Autores principales: Philips, Cyriac, Paramaguru, Rajaguru, Mahadevan, Pushpa, Ravindranath, Jayasurya, Augustine, Philip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2017
Materias:
Nephrology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5453740/
https://www.ncbi.nlm.nih.gov/pubmed/28589058
http://dx.doi.org/10.7759/cureus.1209
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author Philips, Cyriac
Paramaguru, Rajaguru
Mahadevan, Pushpa
Ravindranath, Jayasurya
Augustine, Philip
author_facet Philips, Cyriac
Paramaguru, Rajaguru
Mahadevan, Pushpa
Ravindranath, Jayasurya
Augustine, Philip
author_sort Philips, Cyriac
collection PubMed
description Liver injury caused by metoprolol is very rare with current reports limited to an isolated elevation in transaminases. We report the first case of severe icteric liver injury leading to hepatic encephalopathy secondary to metoprolol use in a patient diagnosed with coronary heart disease. We also describe the histopathology of metoprolol-related liver injury, discuss mechanisms of injury with new insights on the immunological phenomenon, and shed light on the successful utility of early plasmapheresis as a salvage therapy in metoprolol-induced severe liver damage.
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spelling pubmed-54537402017-06-06 Metoprolol-induced Severe Liver Injury and Successful Management with Therapeutic Plasma Exchange Philips, Cyriac Paramaguru, Rajaguru Mahadevan, Pushpa Ravindranath, Jayasurya Augustine, Philip Cureus Nephrology Liver injury caused by metoprolol is very rare with current reports limited to an isolated elevation in transaminases. We report the first case of severe icteric liver injury leading to hepatic encephalopathy secondary to metoprolol use in a patient diagnosed with coronary heart disease. We also describe the histopathology of metoprolol-related liver injury, discuss mechanisms of injury with new insights on the immunological phenomenon, and shed light on the successful utility of early plasmapheresis as a salvage therapy in metoprolol-induced severe liver damage. Cureus 2017-05-02 /pmc/articles/PMC5453740/ /pubmed/28589058 http://dx.doi.org/10.7759/cureus.1209 Text en Copyright © 2017, Philips et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Nephrology
Philips, Cyriac
Paramaguru, Rajaguru
Mahadevan, Pushpa
Ravindranath, Jayasurya
Augustine, Philip
Metoprolol-induced Severe Liver Injury and Successful Management with Therapeutic Plasma Exchange
title Metoprolol-induced Severe Liver Injury and Successful Management with Therapeutic Plasma Exchange
title_full Metoprolol-induced Severe Liver Injury and Successful Management with Therapeutic Plasma Exchange
title_fullStr Metoprolol-induced Severe Liver Injury and Successful Management with Therapeutic Plasma Exchange
title_full_unstemmed Metoprolol-induced Severe Liver Injury and Successful Management with Therapeutic Plasma Exchange
title_short Metoprolol-induced Severe Liver Injury and Successful Management with Therapeutic Plasma Exchange
title_sort metoprolol-induced severe liver injury and successful management with therapeutic plasma exchange
topic Nephrology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5453740/
https://www.ncbi.nlm.nih.gov/pubmed/28589058
http://dx.doi.org/10.7759/cureus.1209
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