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In vivo imaging of uterine cervix with a Mueller polarimetric colposcope

Mueller polarimetric imaging enables the detection and quantification of modifications of the collagen fibers in the uterine cervix due to the development of a precancerous lesion. This information is not accessible through the use of the classic colposcope, a low magnification microscope used in cu...

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Autores principales: Vizet, Jérémy, Rehbinder, Jean, Deby, Stanislas, Roussel, Stéphane, Nazac, André, Soufan, Ranya, Genestie, Catherine, Haie-Meder, Christine, Fernandez, Hervé, Moreau, François, Pierangelo, Angelo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5453972/
https://www.ncbi.nlm.nih.gov/pubmed/28572602
http://dx.doi.org/10.1038/s41598-017-02645-9
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author Vizet, Jérémy
Rehbinder, Jean
Deby, Stanislas
Roussel, Stéphane
Nazac, André
Soufan, Ranya
Genestie, Catherine
Haie-Meder, Christine
Fernandez, Hervé
Moreau, François
Pierangelo, Angelo
author_facet Vizet, Jérémy
Rehbinder, Jean
Deby, Stanislas
Roussel, Stéphane
Nazac, André
Soufan, Ranya
Genestie, Catherine
Haie-Meder, Christine
Fernandez, Hervé
Moreau, François
Pierangelo, Angelo
author_sort Vizet, Jérémy
collection PubMed
description Mueller polarimetric imaging enables the detection and quantification of modifications of the collagen fibers in the uterine cervix due to the development of a precancerous lesion. This information is not accessible through the use of the classic colposcope, a low magnification microscope used in current practice for cervical cancer screening. However, the in vivo application of Mueller polarimetric imaging poses an instrumental challenge: the device should be sufficiently compact, while still being able to perform fast and accurate acquisition of Mueller matrices in real-world conditions. In this study, the first wide field Mueller Polarimetric Colposcope (MPC) for the in vivo analysis of uterine cervix is presented. The MPC has been fabricated by grafting a miniaturized Mueller polarimetric imager on a classic colposcope. This new imaging tool performs the fast acquisition of Mueller polarimetric images, thus eliminating any blurring effects due to patient movements. It can be easily used by a practitioner with little change to their existing practice. Finally, the MPC was tested in vivo on a number of patients in the field.
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spelling pubmed-54539722017-06-06 In vivo imaging of uterine cervix with a Mueller polarimetric colposcope Vizet, Jérémy Rehbinder, Jean Deby, Stanislas Roussel, Stéphane Nazac, André Soufan, Ranya Genestie, Catherine Haie-Meder, Christine Fernandez, Hervé Moreau, François Pierangelo, Angelo Sci Rep Article Mueller polarimetric imaging enables the detection and quantification of modifications of the collagen fibers in the uterine cervix due to the development of a precancerous lesion. This information is not accessible through the use of the classic colposcope, a low magnification microscope used in current practice for cervical cancer screening. However, the in vivo application of Mueller polarimetric imaging poses an instrumental challenge: the device should be sufficiently compact, while still being able to perform fast and accurate acquisition of Mueller matrices in real-world conditions. In this study, the first wide field Mueller Polarimetric Colposcope (MPC) for the in vivo analysis of uterine cervix is presented. The MPC has been fabricated by grafting a miniaturized Mueller polarimetric imager on a classic colposcope. This new imaging tool performs the fast acquisition of Mueller polarimetric images, thus eliminating any blurring effects due to patient movements. It can be easily used by a practitioner with little change to their existing practice. Finally, the MPC was tested in vivo on a number of patients in the field. Nature Publishing Group UK 2017-06-01 /pmc/articles/PMC5453972/ /pubmed/28572602 http://dx.doi.org/10.1038/s41598-017-02645-9 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Vizet, Jérémy
Rehbinder, Jean
Deby, Stanislas
Roussel, Stéphane
Nazac, André
Soufan, Ranya
Genestie, Catherine
Haie-Meder, Christine
Fernandez, Hervé
Moreau, François
Pierangelo, Angelo
In vivo imaging of uterine cervix with a Mueller polarimetric colposcope
title In vivo imaging of uterine cervix with a Mueller polarimetric colposcope
title_full In vivo imaging of uterine cervix with a Mueller polarimetric colposcope
title_fullStr In vivo imaging of uterine cervix with a Mueller polarimetric colposcope
title_full_unstemmed In vivo imaging of uterine cervix with a Mueller polarimetric colposcope
title_short In vivo imaging of uterine cervix with a Mueller polarimetric colposcope
title_sort in vivo imaging of uterine cervix with a mueller polarimetric colposcope
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5453972/
https://www.ncbi.nlm.nih.gov/pubmed/28572602
http://dx.doi.org/10.1038/s41598-017-02645-9
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