Neoglycoconjugate of Tetrasaccharide Representing One Repeating Unit of the Streptococcus pneumoniae Type 14 Capsular Polysaccharide Induces the Production of Opsonizing IgG1 Antibodies and Possesses the Highest Protective Activity As Compared to Hexa- and Octasaccharide Conjugates

Identifying protective synthetic oligosaccharide (OS) epitopes of Streptococcus pneumoniae capsular polysaccharides (CPs) is an indispensable step in the development of third-generation carbohydrate pneumococcal vaccines. Synthetic tetra-, hexa-, and octasaccharide structurally related to CP of S. p...

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Detalles Bibliográficos
Autores principales: Kurbatova, Ekaterina A., Akhmatova, Nelli K., Akhmatova, Elina A., Egorova, Nadezhda B., Yastrebova, Natalya E., Sukhova, Elena V., Yashunsky, Dmitriy V., Tsvetkov, Yury E., Gening, Marina L., Nifantiev, Nikolay E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5454037/
https://www.ncbi.nlm.nih.gov/pubmed/28626461
http://dx.doi.org/10.3389/fimmu.2017.00659

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