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Factor V has an anticoagulant cofactor activity that targets the early phase of coagulation

Tissue factor pathway inhibitor (TFPI), the main inhibitor of initiation of coagulation, exerts an important anticoagulant role through the factor Xa (FXa)-dependent inhibition of tissue factor/factor VIIa. Protein S is a TFPI cofactor, enhancing the efficiency of FXa inhibition. TFPI can also inhib...

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Detalles Bibliográficos
Autores principales:	Santamaria, Salvatore, Reglińska-Matveyev, Natalia, Gierula, Magdalena, Camire, Rodney M., Crawley, James T. B., Lane, David A., Ahnström, Josefin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2017
Materias:	Enzymology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5454113/ https://www.ncbi.nlm.nih.gov/pubmed/28420729 http://dx.doi.org/10.1074/jbc.M116.769570

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