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Emergence of Wesselsbron virus among black rat and humans in Eastern Senegal in 2013
Wesselsbron disease is a neglected mosquito transmitted Flavivirus infection that causes abortions and has teratogenic effects on sheep and cattle in Africa. Human can also be infected. The detection of human or animal cases is complicated by the non-specific symptoms close to Rift Valley Fever (RVF...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5454166/ https://www.ncbi.nlm.nih.gov/pubmed/28616499 http://dx.doi.org/10.1016/j.onehlt.2017.02.001 |
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author | Diagne, Moussa M. Faye, Martin Faye, Oumar Sow, Abdourahmane Balique, Fanny Sembène, Mbacké Granjon, Laurent Handschumacher, Pascal Faye, Ousmane Diallo, Mawlouth Sall, Amadou A. |
author_facet | Diagne, Moussa M. Faye, Martin Faye, Oumar Sow, Abdourahmane Balique, Fanny Sembène, Mbacké Granjon, Laurent Handschumacher, Pascal Faye, Ousmane Diallo, Mawlouth Sall, Amadou A. |
author_sort | Diagne, Moussa M. |
collection | PubMed |
description | Wesselsbron disease is a neglected mosquito transmitted Flavivirus infection that causes abortions and has teratogenic effects on sheep and cattle in Africa. Human can also be infected. The detection of human or animal cases is complicated by the non-specific symptoms close to Rift Valley Fever (RVF) in domestic livestock species or Dengue like syndrome in humans. Then, these detections are usually made during RVF investigations in sheep. These domestic animals should take a role in the life cycle of the virus but some evidences of Wesselsbron virus (WSLV) presence in wild animals suggest that the latter may be involved in the virus maintenance in nature. However, the reservoir status of wild vertebrate in general and rodents particularly for WSLV is only based on an isolation from a Cape short-eared gerbil in southern Africa. Most of WSLV isolations are from southern parts of Africa even if it has been found in western and central Africa or Madagascar. In Senegal, there are serological evidences of WSLV circulation in human since the 1970s and some isolations, the last one of which dates back in 1992. Despite the detection of the virus on mosquitoes until the 2000s in different parts of the country, no new human case has been noted. In this paper, we report the WSLV re-emergence in eastern Senegal in 2013 with 2 human cases and its first isolation from a black rat Rattus rattus. Sequencing analyses show the circulation of the same strain between these humans and the commensal rodent. The putative impact on WSLV transmission to human populations could be more important if the reservoir status of the black rat is confirmed. Focused survey in human populations, specific entomological and mammalogical investigations would permit a better understanding of the life cycle of the virus and its impact on public health. |
format | Online Article Text |
id | pubmed-5454166 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-54541662017-06-14 Emergence of Wesselsbron virus among black rat and humans in Eastern Senegal in 2013 Diagne, Moussa M. Faye, Martin Faye, Oumar Sow, Abdourahmane Balique, Fanny Sembène, Mbacké Granjon, Laurent Handschumacher, Pascal Faye, Ousmane Diallo, Mawlouth Sall, Amadou A. One Health Research Paper Wesselsbron disease is a neglected mosquito transmitted Flavivirus infection that causes abortions and has teratogenic effects on sheep and cattle in Africa. Human can also be infected. The detection of human or animal cases is complicated by the non-specific symptoms close to Rift Valley Fever (RVF) in domestic livestock species or Dengue like syndrome in humans. Then, these detections are usually made during RVF investigations in sheep. These domestic animals should take a role in the life cycle of the virus but some evidences of Wesselsbron virus (WSLV) presence in wild animals suggest that the latter may be involved in the virus maintenance in nature. However, the reservoir status of wild vertebrate in general and rodents particularly for WSLV is only based on an isolation from a Cape short-eared gerbil in southern Africa. Most of WSLV isolations are from southern parts of Africa even if it has been found in western and central Africa or Madagascar. In Senegal, there are serological evidences of WSLV circulation in human since the 1970s and some isolations, the last one of which dates back in 1992. Despite the detection of the virus on mosquitoes until the 2000s in different parts of the country, no new human case has been noted. In this paper, we report the WSLV re-emergence in eastern Senegal in 2013 with 2 human cases and its first isolation from a black rat Rattus rattus. Sequencing analyses show the circulation of the same strain between these humans and the commensal rodent. The putative impact on WSLV transmission to human populations could be more important if the reservoir status of the black rat is confirmed. Focused survey in human populations, specific entomological and mammalogical investigations would permit a better understanding of the life cycle of the virus and its impact on public health. Elsevier 2017-02-09 /pmc/articles/PMC5454166/ /pubmed/28616499 http://dx.doi.org/10.1016/j.onehlt.2017.02.001 Text en © 2017 Published by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Research Paper Diagne, Moussa M. Faye, Martin Faye, Oumar Sow, Abdourahmane Balique, Fanny Sembène, Mbacké Granjon, Laurent Handschumacher, Pascal Faye, Ousmane Diallo, Mawlouth Sall, Amadou A. Emergence of Wesselsbron virus among black rat and humans in Eastern Senegal in 2013 |
title | Emergence of Wesselsbron virus among black rat and humans in Eastern Senegal in 2013 |
title_full | Emergence of Wesselsbron virus among black rat and humans in Eastern Senegal in 2013 |
title_fullStr | Emergence of Wesselsbron virus among black rat and humans in Eastern Senegal in 2013 |
title_full_unstemmed | Emergence of Wesselsbron virus among black rat and humans in Eastern Senegal in 2013 |
title_short | Emergence of Wesselsbron virus among black rat and humans in Eastern Senegal in 2013 |
title_sort | emergence of wesselsbron virus among black rat and humans in eastern senegal in 2013 |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5454166/ https://www.ncbi.nlm.nih.gov/pubmed/28616499 http://dx.doi.org/10.1016/j.onehlt.2017.02.001 |
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