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Reducing cardiac doses: a novel multi‐leaf collimator modification technique to reduce left anterior descending coronary artery dose in patients with left‐sided breast cancer

INTRODUCTION: When irradiating the left breast, a small portion of the heart and left anterior descending coronary artery (LAD) are often included in the treatment field. Deep inspiration breath‐hold (DIBH) techniques reduce dose to coronary structures, but are resource intensive and may not be tole...

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Autores principales: Welsh, Briana, Chao, Michael, Foroudi, Farshad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5454332/
https://www.ncbi.nlm.nih.gov/pubmed/27741387
http://dx.doi.org/10.1002/jmrs.191
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author Welsh, Briana
Chao, Michael
Foroudi, Farshad
author_facet Welsh, Briana
Chao, Michael
Foroudi, Farshad
author_sort Welsh, Briana
collection PubMed
description INTRODUCTION: When irradiating the left breast, a small portion of the heart and left anterior descending coronary artery (LAD) are often included in the treatment field. Deep inspiration breath‐hold (DIBH) techniques reduce dose to coronary structures, but are resource intensive and may not be tolerated by all patients. The aim of this study was to evaluate a simple multi‐leaf collimator (MLC) modification technique with respect to target coverage and organ‐at‐risk sparing. METHODS: Forty nine patients with left‐sided breast cancer, planned with a simultaneous integrated boost technique were retrospectively replanned with additional shielding of the LAD. Dose to the target volumes (whole breast and boost) and organs at risk (heart, ipsilateral lung and LAD) were assessed on both plans. RESULTS: Significant dose reductions were observed for all organs at risk when LAD shielding was introduced, with a reduction in mean LAD dose of 7.0 Gy, mean LAD planning risk volume (PRV) dose of 5.9 Gy, maximum LAD dose of 12 Gy and mean heart dose of 0.73 Gy. Target volume coverage was clinically acceptable for 96% of patients, using the left anterior descending coronary artery shielded plan (LADSP). No difference was observed between the standard plan (SP) and LADSP in nine patients (18%). CONCLUSIONS: For selected patients, the implementation of a simple MLC shielding technique can reduce the dose to cardiac structures, whilst maintaining breast and boost volume dosimetry. This technique is simple to implement and may be used as an alternative to DIBH for those patients who are unable to fulfill the selection criteria, or departments who are not resourced to perform DIBH.
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spelling pubmed-54543322017-06-06 Reducing cardiac doses: a novel multi‐leaf collimator modification technique to reduce left anterior descending coronary artery dose in patients with left‐sided breast cancer Welsh, Briana Chao, Michael Foroudi, Farshad J Med Radiat Sci Original Articles INTRODUCTION: When irradiating the left breast, a small portion of the heart and left anterior descending coronary artery (LAD) are often included in the treatment field. Deep inspiration breath‐hold (DIBH) techniques reduce dose to coronary structures, but are resource intensive and may not be tolerated by all patients. The aim of this study was to evaluate a simple multi‐leaf collimator (MLC) modification technique with respect to target coverage and organ‐at‐risk sparing. METHODS: Forty nine patients with left‐sided breast cancer, planned with a simultaneous integrated boost technique were retrospectively replanned with additional shielding of the LAD. Dose to the target volumes (whole breast and boost) and organs at risk (heart, ipsilateral lung and LAD) were assessed on both plans. RESULTS: Significant dose reductions were observed for all organs at risk when LAD shielding was introduced, with a reduction in mean LAD dose of 7.0 Gy, mean LAD planning risk volume (PRV) dose of 5.9 Gy, maximum LAD dose of 12 Gy and mean heart dose of 0.73 Gy. Target volume coverage was clinically acceptable for 96% of patients, using the left anterior descending coronary artery shielded plan (LADSP). No difference was observed between the standard plan (SP) and LADSP in nine patients (18%). CONCLUSIONS: For selected patients, the implementation of a simple MLC shielding technique can reduce the dose to cardiac structures, whilst maintaining breast and boost volume dosimetry. This technique is simple to implement and may be used as an alternative to DIBH for those patients who are unable to fulfill the selection criteria, or departments who are not resourced to perform DIBH. John Wiley and Sons Inc. 2016-09-09 2017-06 /pmc/articles/PMC5454332/ /pubmed/27741387 http://dx.doi.org/10.1002/jmrs.191 Text en © 2016 The Authors. Journal of Medical Radiation Sciences published by John Wiley & Sons Australia, Ltd on behalf of Australian Society of Medical Imaging and Radiation Therapy and New Zealand Institute of Medical Radiation Technology. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs (http://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Original Articles
Welsh, Briana
Chao, Michael
Foroudi, Farshad
Reducing cardiac doses: a novel multi‐leaf collimator modification technique to reduce left anterior descending coronary artery dose in patients with left‐sided breast cancer
title Reducing cardiac doses: a novel multi‐leaf collimator modification technique to reduce left anterior descending coronary artery dose in patients with left‐sided breast cancer
title_full Reducing cardiac doses: a novel multi‐leaf collimator modification technique to reduce left anterior descending coronary artery dose in patients with left‐sided breast cancer
title_fullStr Reducing cardiac doses: a novel multi‐leaf collimator modification technique to reduce left anterior descending coronary artery dose in patients with left‐sided breast cancer
title_full_unstemmed Reducing cardiac doses: a novel multi‐leaf collimator modification technique to reduce left anterior descending coronary artery dose in patients with left‐sided breast cancer
title_short Reducing cardiac doses: a novel multi‐leaf collimator modification technique to reduce left anterior descending coronary artery dose in patients with left‐sided breast cancer
title_sort reducing cardiac doses: a novel multi‐leaf collimator modification technique to reduce left anterior descending coronary artery dose in patients with left‐sided breast cancer
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5454332/
https://www.ncbi.nlm.nih.gov/pubmed/27741387
http://dx.doi.org/10.1002/jmrs.191
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