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Artificial local magnetic field inhomogeneity enhances T(2) relaxivity
Clustering of magnetic nanoparticles (MNPs) is perhaps the most effective, yet intriguing strategy to enhance T(2) relaxivity in magnetic resonance imaging (MRI). However, the underlying mechanism is still not fully understood and the attempts to generalize the classic outersphere theory from single...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5454366/ https://www.ncbi.nlm.nih.gov/pubmed/28516947 http://dx.doi.org/10.1038/ncomms15468 |
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author | Zhou, Zijian Tian, Rui Wang, Zhenyu Yang, Zhen Liu, Yijing Liu, Gang Wang, Ruifang Gao, Jinhao Song, Jibin Nie, Liming Chen, Xiaoyuan |
author_facet | Zhou, Zijian Tian, Rui Wang, Zhenyu Yang, Zhen Liu, Yijing Liu, Gang Wang, Ruifang Gao, Jinhao Song, Jibin Nie, Liming Chen, Xiaoyuan |
author_sort | Zhou, Zijian |
collection | PubMed |
description | Clustering of magnetic nanoparticles (MNPs) is perhaps the most effective, yet intriguing strategy to enhance T(2) relaxivity in magnetic resonance imaging (MRI). However, the underlying mechanism is still not fully understood and the attempts to generalize the classic outersphere theory from single particles to clusters have been found to be inadequate. Here we show that clustering of MNPs enhances local field inhomogeneity due to reduced field symmetry, which can be further elevated by artificially involving iron oxide NPs with heterogeneous geometries in terms of size and shape. The r(2) values of iron oxide clusters and Landau–Lifshitz–Gilbert simulations confirmed our hypothesis, indicating that solving magnetic field inhomogeneity may become a powerful way to build correlation between magnetization and T(2) relaxivity of MNPs, especially magnetic clusters. This study provides a simple yet distinct mechanism to interpret T(2) relaxivity of MNPs, which is crucial to the design of high-performance MRI contrast agents. |
format | Online Article Text |
id | pubmed-5454366 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-54543662017-06-07 Artificial local magnetic field inhomogeneity enhances T(2) relaxivity Zhou, Zijian Tian, Rui Wang, Zhenyu Yang, Zhen Liu, Yijing Liu, Gang Wang, Ruifang Gao, Jinhao Song, Jibin Nie, Liming Chen, Xiaoyuan Nat Commun Article Clustering of magnetic nanoparticles (MNPs) is perhaps the most effective, yet intriguing strategy to enhance T(2) relaxivity in magnetic resonance imaging (MRI). However, the underlying mechanism is still not fully understood and the attempts to generalize the classic outersphere theory from single particles to clusters have been found to be inadequate. Here we show that clustering of MNPs enhances local field inhomogeneity due to reduced field symmetry, which can be further elevated by artificially involving iron oxide NPs with heterogeneous geometries in terms of size and shape. The r(2) values of iron oxide clusters and Landau–Lifshitz–Gilbert simulations confirmed our hypothesis, indicating that solving magnetic field inhomogeneity may become a powerful way to build correlation between magnetization and T(2) relaxivity of MNPs, especially magnetic clusters. This study provides a simple yet distinct mechanism to interpret T(2) relaxivity of MNPs, which is crucial to the design of high-performance MRI contrast agents. Nature Publishing Group 2017-05-18 /pmc/articles/PMC5454366/ /pubmed/28516947 http://dx.doi.org/10.1038/ncomms15468 Text en Copyright © 2017, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Zhou, Zijian Tian, Rui Wang, Zhenyu Yang, Zhen Liu, Yijing Liu, Gang Wang, Ruifang Gao, Jinhao Song, Jibin Nie, Liming Chen, Xiaoyuan Artificial local magnetic field inhomogeneity enhances T(2) relaxivity |
title | Artificial local magnetic field inhomogeneity enhances T(2) relaxivity |
title_full | Artificial local magnetic field inhomogeneity enhances T(2) relaxivity |
title_fullStr | Artificial local magnetic field inhomogeneity enhances T(2) relaxivity |
title_full_unstemmed | Artificial local magnetic field inhomogeneity enhances T(2) relaxivity |
title_short | Artificial local magnetic field inhomogeneity enhances T(2) relaxivity |
title_sort | artificial local magnetic field inhomogeneity enhances t(2) relaxivity |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5454366/ https://www.ncbi.nlm.nih.gov/pubmed/28516947 http://dx.doi.org/10.1038/ncomms15468 |
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