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Artificial local magnetic field inhomogeneity enhances T(2) relaxivity

Clustering of magnetic nanoparticles (MNPs) is perhaps the most effective, yet intriguing strategy to enhance T(2) relaxivity in magnetic resonance imaging (MRI). However, the underlying mechanism is still not fully understood and the attempts to generalize the classic outersphere theory from single...

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Autores principales: Zhou, Zijian, Tian, Rui, Wang, Zhenyu, Yang, Zhen, Liu, Yijing, Liu, Gang, Wang, Ruifang, Gao, Jinhao, Song, Jibin, Nie, Liming, Chen, Xiaoyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5454366/
https://www.ncbi.nlm.nih.gov/pubmed/28516947
http://dx.doi.org/10.1038/ncomms15468
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author Zhou, Zijian
Tian, Rui
Wang, Zhenyu
Yang, Zhen
Liu, Yijing
Liu, Gang
Wang, Ruifang
Gao, Jinhao
Song, Jibin
Nie, Liming
Chen, Xiaoyuan
author_facet Zhou, Zijian
Tian, Rui
Wang, Zhenyu
Yang, Zhen
Liu, Yijing
Liu, Gang
Wang, Ruifang
Gao, Jinhao
Song, Jibin
Nie, Liming
Chen, Xiaoyuan
author_sort Zhou, Zijian
collection PubMed
description Clustering of magnetic nanoparticles (MNPs) is perhaps the most effective, yet intriguing strategy to enhance T(2) relaxivity in magnetic resonance imaging (MRI). However, the underlying mechanism is still not fully understood and the attempts to generalize the classic outersphere theory from single particles to clusters have been found to be inadequate. Here we show that clustering of MNPs enhances local field inhomogeneity due to reduced field symmetry, which can be further elevated by artificially involving iron oxide NPs with heterogeneous geometries in terms of size and shape. The r(2) values of iron oxide clusters and Landau–Lifshitz–Gilbert simulations confirmed our hypothesis, indicating that solving magnetic field inhomogeneity may become a powerful way to build correlation between magnetization and T(2) relaxivity of MNPs, especially magnetic clusters. This study provides a simple yet distinct mechanism to interpret T(2) relaxivity of MNPs, which is crucial to the design of high-performance MRI contrast agents.
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spelling pubmed-54543662017-06-07 Artificial local magnetic field inhomogeneity enhances T(2) relaxivity Zhou, Zijian Tian, Rui Wang, Zhenyu Yang, Zhen Liu, Yijing Liu, Gang Wang, Ruifang Gao, Jinhao Song, Jibin Nie, Liming Chen, Xiaoyuan Nat Commun Article Clustering of magnetic nanoparticles (MNPs) is perhaps the most effective, yet intriguing strategy to enhance T(2) relaxivity in magnetic resonance imaging (MRI). However, the underlying mechanism is still not fully understood and the attempts to generalize the classic outersphere theory from single particles to clusters have been found to be inadequate. Here we show that clustering of MNPs enhances local field inhomogeneity due to reduced field symmetry, which can be further elevated by artificially involving iron oxide NPs with heterogeneous geometries in terms of size and shape. The r(2) values of iron oxide clusters and Landau–Lifshitz–Gilbert simulations confirmed our hypothesis, indicating that solving magnetic field inhomogeneity may become a powerful way to build correlation between magnetization and T(2) relaxivity of MNPs, especially magnetic clusters. This study provides a simple yet distinct mechanism to interpret T(2) relaxivity of MNPs, which is crucial to the design of high-performance MRI contrast agents. Nature Publishing Group 2017-05-18 /pmc/articles/PMC5454366/ /pubmed/28516947 http://dx.doi.org/10.1038/ncomms15468 Text en Copyright © 2017, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Zhou, Zijian
Tian, Rui
Wang, Zhenyu
Yang, Zhen
Liu, Yijing
Liu, Gang
Wang, Ruifang
Gao, Jinhao
Song, Jibin
Nie, Liming
Chen, Xiaoyuan
Artificial local magnetic field inhomogeneity enhances T(2) relaxivity
title Artificial local magnetic field inhomogeneity enhances T(2) relaxivity
title_full Artificial local magnetic field inhomogeneity enhances T(2) relaxivity
title_fullStr Artificial local magnetic field inhomogeneity enhances T(2) relaxivity
title_full_unstemmed Artificial local magnetic field inhomogeneity enhances T(2) relaxivity
title_short Artificial local magnetic field inhomogeneity enhances T(2) relaxivity
title_sort artificial local magnetic field inhomogeneity enhances t(2) relaxivity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5454366/
https://www.ncbi.nlm.nih.gov/pubmed/28516947
http://dx.doi.org/10.1038/ncomms15468
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