Selective BET bromodomain inhibition as an antifungal therapeutic strategy

Invasive fungal infections cause significant morbidity and mortality among immunocompromised individuals, posing an urgent need for new antifungal therapeutic strategies. Here we investigate a chromatin-interacting module, the bromodomain (BD) from the BET family of proteins, as a potential antifung...

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Detalles Bibliográficos
Autores principales: Mietton, Flore, Ferri, Elena, Champleboux, Morgane, Zala, Ninon, Maubon, Danièle, Zhou, Yingsheng, Harbut, Mike, Spittler, Didier, Garnaud, Cécile, Courçon, Marie, Chauvel, Murielle, d'Enfert, Christophe, Kashemirov, Boris A., Hull, Mitchell, Cornet, Muriel, McKenna, Charles E., Govin, Jérôme, Petosa, Carlo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5454392/
https://www.ncbi.nlm.nih.gov/pubmed/28516956
http://dx.doi.org/10.1038/ncomms15482

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