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Impact of Early Consumption of High-Fat Diet on the Mesolimbic Dopaminergic System

Increasing evidence suggest that consumption of high-fat diet (HFD) can impact the maturation of brain circuits, such as during adolescence, which could account for behavioral alterations associated with obesity. In the present study, we used behavioral sensitization to amphetamine to investigate th...

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Autores principales: Naneix, F., Tantot, F., Glangetas, C., Kaufling, J., Janthakhin, Y., Boitard, C., De Smedt-Peyrusse, V., Pape, J. R., Vancassel, S., Trifilieff, P., Georges, F., Coutureau, E., Ferreira, G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5454405/
https://www.ncbi.nlm.nih.gov/pubmed/28580417
http://dx.doi.org/10.1523/ENEURO.0120-17.2017
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author Naneix, F.
Tantot, F.
Glangetas, C.
Kaufling, J.
Janthakhin, Y.
Boitard, C.
De Smedt-Peyrusse, V.
Pape, J. R.
Vancassel, S.
Trifilieff, P.
Georges, F.
Coutureau, E.
Ferreira, G.
author_facet Naneix, F.
Tantot, F.
Glangetas, C.
Kaufling, J.
Janthakhin, Y.
Boitard, C.
De Smedt-Peyrusse, V.
Pape, J. R.
Vancassel, S.
Trifilieff, P.
Georges, F.
Coutureau, E.
Ferreira, G.
author_sort Naneix, F.
collection PubMed
description Increasing evidence suggest that consumption of high-fat diet (HFD) can impact the maturation of brain circuits, such as during adolescence, which could account for behavioral alterations associated with obesity. In the present study, we used behavioral sensitization to amphetamine to investigate the effect of periadolescent HFD exposure (pHFD) in rats on the functionality of the dopamine (DA) system, a central actor in food reward processing. pHFD does not affect responding to an acute injection, however, a single exposure to amphetamine is sufficient to induce locomotor sensitization in pHFD rats. This is paralleled by rapid neurobiological adaptations within the DA system. In pHFD-exposed animals, a single amphetamine exposure induces an increase in bursting activity of DA cells in the ventral tegmental area (VTA) as well as higher DA release and greater expression of (tyrosine hydroxylase, TH) in the nucleus accumbens (NAc). Post-synaptically, pHFD animals display an increase in NAc D2 receptors and c-Fos expression after amphetamine injection. These findings highlight the vulnerability of DA system to the consumption of HFD during adolescence that may support deficits in reward-related processes observed in obesity.
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spelling pubmed-54544052017-06-02 Impact of Early Consumption of High-Fat Diet on the Mesolimbic Dopaminergic System Naneix, F. Tantot, F. Glangetas, C. Kaufling, J. Janthakhin, Y. Boitard, C. De Smedt-Peyrusse, V. Pape, J. R. Vancassel, S. Trifilieff, P. Georges, F. Coutureau, E. Ferreira, G. eNeuro New Research Increasing evidence suggest that consumption of high-fat diet (HFD) can impact the maturation of brain circuits, such as during adolescence, which could account for behavioral alterations associated with obesity. In the present study, we used behavioral sensitization to amphetamine to investigate the effect of periadolescent HFD exposure (pHFD) in rats on the functionality of the dopamine (DA) system, a central actor in food reward processing. pHFD does not affect responding to an acute injection, however, a single exposure to amphetamine is sufficient to induce locomotor sensitization in pHFD rats. This is paralleled by rapid neurobiological adaptations within the DA system. In pHFD-exposed animals, a single amphetamine exposure induces an increase in bursting activity of DA cells in the ventral tegmental area (VTA) as well as higher DA release and greater expression of (tyrosine hydroxylase, TH) in the nucleus accumbens (NAc). Post-synaptically, pHFD animals display an increase in NAc D2 receptors and c-Fos expression after amphetamine injection. These findings highlight the vulnerability of DA system to the consumption of HFD during adolescence that may support deficits in reward-related processes observed in obesity. Society for Neuroscience 2017-06-01 /pmc/articles/PMC5454405/ /pubmed/28580417 http://dx.doi.org/10.1523/ENEURO.0120-17.2017 Text en Copyright © 2017 Naneix et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
spellingShingle New Research
Naneix, F.
Tantot, F.
Glangetas, C.
Kaufling, J.
Janthakhin, Y.
Boitard, C.
De Smedt-Peyrusse, V.
Pape, J. R.
Vancassel, S.
Trifilieff, P.
Georges, F.
Coutureau, E.
Ferreira, G.
Impact of Early Consumption of High-Fat Diet on the Mesolimbic Dopaminergic System
title Impact of Early Consumption of High-Fat Diet on the Mesolimbic Dopaminergic System
title_full Impact of Early Consumption of High-Fat Diet on the Mesolimbic Dopaminergic System
title_fullStr Impact of Early Consumption of High-Fat Diet on the Mesolimbic Dopaminergic System
title_full_unstemmed Impact of Early Consumption of High-Fat Diet on the Mesolimbic Dopaminergic System
title_short Impact of Early Consumption of High-Fat Diet on the Mesolimbic Dopaminergic System
title_sort impact of early consumption of high-fat diet on the mesolimbic dopaminergic system
topic New Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5454405/
https://www.ncbi.nlm.nih.gov/pubmed/28580417
http://dx.doi.org/10.1523/ENEURO.0120-17.2017
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