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Optimized fragmentation schemes and data analysis strategies for proteome-wide cross-link identification

We describe optimized fragmentation schemes and data analysis strategies substantially enhancing the depth and accuracy in identifying protein cross-links using non-restricted whole proteome databases. These include a novel hybrid data acquisition strategy to sequence cross-links at both MS2 and MS3...

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Detalles Bibliográficos
Autores principales:	Liu, Fan, Lössl, Philip, Scheltema, Richard, Viner, Rosa, Heck, Albert J. R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5454533/ https://www.ncbi.nlm.nih.gov/pubmed/28524877 http://dx.doi.org/10.1038/ncomms15473

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