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Adverse Health Effects of Thirdhand Smoke: From Cell to Animal Models

The newly identified smoke hazard, thirdhand smoke (THS), has gained public attention in recent years but its health impact and biological effects are largely unknown. THS may be defined by “the four Rs”: tobacco chemicals that remain, react, re-emit, and/or are resuspended long after active smoking...

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Detalles Bibliográficos
Autores principales: Hang, Bo, Wang, Pin, Zhao, Yue, Sarker, Altaf, Chenna, Ahmed, Xia, Yankai, Snijders, Antoine M., Mao, Jian-Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5454845/
https://www.ncbi.nlm.nih.gov/pubmed/28452951
http://dx.doi.org/10.3390/ijms18050932
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author Hang, Bo
Wang, Pin
Zhao, Yue
Sarker, Altaf
Chenna, Ahmed
Xia, Yankai
Snijders, Antoine M.
Mao, Jian-Hua
author_facet Hang, Bo
Wang, Pin
Zhao, Yue
Sarker, Altaf
Chenna, Ahmed
Xia, Yankai
Snijders, Antoine M.
Mao, Jian-Hua
author_sort Hang, Bo
collection PubMed
description The newly identified smoke hazard, thirdhand smoke (THS), has gained public attention in recent years but its health impact and biological effects are largely unknown. THS may be defined by “the four Rs”: tobacco chemicals that remain, react, re-emit, and/or are resuspended long after active smoking has ceased. This review summarizes recent research progress in the effects of THS on genotoxicity, metabolism and early life development using cellular and animal models. We first reported that THS generated in laboratory systems caused significant DNA damage in human cell lines. Our finding that THS significantly induces oxidative base lesions has been confirmed in skin wounds of mice models exposed to THS. THS also induced metabolomic changes in human reproductive cell lines. Furthermore, we demonstrated that early exposure to THS not only negatively impacts body weight in both male and female mice, but also induces persistent changes to immunological parameters in peripheral blood in these mice. These results indicate that THS is genotoxic at realistic experimental doses and that there may be a window of susceptibility for some forms of cellular damage induced by THS.
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spelling pubmed-54548452017-06-08 Adverse Health Effects of Thirdhand Smoke: From Cell to Animal Models Hang, Bo Wang, Pin Zhao, Yue Sarker, Altaf Chenna, Ahmed Xia, Yankai Snijders, Antoine M. Mao, Jian-Hua Int J Mol Sci Review The newly identified smoke hazard, thirdhand smoke (THS), has gained public attention in recent years but its health impact and biological effects are largely unknown. THS may be defined by “the four Rs”: tobacco chemicals that remain, react, re-emit, and/or are resuspended long after active smoking has ceased. This review summarizes recent research progress in the effects of THS on genotoxicity, metabolism and early life development using cellular and animal models. We first reported that THS generated in laboratory systems caused significant DNA damage in human cell lines. Our finding that THS significantly induces oxidative base lesions has been confirmed in skin wounds of mice models exposed to THS. THS also induced metabolomic changes in human reproductive cell lines. Furthermore, we demonstrated that early exposure to THS not only negatively impacts body weight in both male and female mice, but also induces persistent changes to immunological parameters in peripheral blood in these mice. These results indicate that THS is genotoxic at realistic experimental doses and that there may be a window of susceptibility for some forms of cellular damage induced by THS. MDPI 2017-04-28 /pmc/articles/PMC5454845/ /pubmed/28452951 http://dx.doi.org/10.3390/ijms18050932 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Hang, Bo
Wang, Pin
Zhao, Yue
Sarker, Altaf
Chenna, Ahmed
Xia, Yankai
Snijders, Antoine M.
Mao, Jian-Hua
Adverse Health Effects of Thirdhand Smoke: From Cell to Animal Models
title Adverse Health Effects of Thirdhand Smoke: From Cell to Animal Models
title_full Adverse Health Effects of Thirdhand Smoke: From Cell to Animal Models
title_fullStr Adverse Health Effects of Thirdhand Smoke: From Cell to Animal Models
title_full_unstemmed Adverse Health Effects of Thirdhand Smoke: From Cell to Animal Models
title_short Adverse Health Effects of Thirdhand Smoke: From Cell to Animal Models
title_sort adverse health effects of thirdhand smoke: from cell to animal models
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5454845/
https://www.ncbi.nlm.nih.gov/pubmed/28452951
http://dx.doi.org/10.3390/ijms18050932
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