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Association of Extracellular Membrane Vesicles with Cutaneous Wound Healing

Extracellular vesicles (EVs) are membrane-enclosed vesicles that are released into the extracellular environment by various cell types, which can be classified as apoptotic bodies, microvesicles and exosomes. EVs have been shown to carry DNA, small RNAs, proteins and membrane lipids which are derive...

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Detalles Bibliográficos
Autores principales: Than, Uyen Thi Trang, Guanzon, Dominic, Leavesley, David, Parker, Tony
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5454869/
https://www.ncbi.nlm.nih.gov/pubmed/28468315
http://dx.doi.org/10.3390/ijms18050956
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author Than, Uyen Thi Trang
Guanzon, Dominic
Leavesley, David
Parker, Tony
author_facet Than, Uyen Thi Trang
Guanzon, Dominic
Leavesley, David
Parker, Tony
author_sort Than, Uyen Thi Trang
collection PubMed
description Extracellular vesicles (EVs) are membrane-enclosed vesicles that are released into the extracellular environment by various cell types, which can be classified as apoptotic bodies, microvesicles and exosomes. EVs have been shown to carry DNA, small RNAs, proteins and membrane lipids which are derived from the parental cells. Recently, several studies have demonstrated that EVs can regulate many biological processes, such as cancer progression, the immune response, cell proliferation, cell migration and blood vessel tube formation. This regulation is achieved through the release and transport of EVs and the transfer of their parental cell-derived molecular cargo to recipient cells. This thereby influences various physiological and sometimes pathological functions within the target cells. While intensive investigation of EVs has focused on pathological processes, the involvement of EVs in normal wound healing is less clear; however, recent preliminarily investigations have produced some initial insights. This review will provide an overview of EVs and discuss the current literature regarding the role of EVs in wound healing, especially, their influence on coagulation, cell proliferation, migration, angiogenesis, collagen production and extracellular matrix remodelling.
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spelling pubmed-54548692017-06-08 Association of Extracellular Membrane Vesicles with Cutaneous Wound Healing Than, Uyen Thi Trang Guanzon, Dominic Leavesley, David Parker, Tony Int J Mol Sci Review Extracellular vesicles (EVs) are membrane-enclosed vesicles that are released into the extracellular environment by various cell types, which can be classified as apoptotic bodies, microvesicles and exosomes. EVs have been shown to carry DNA, small RNAs, proteins and membrane lipids which are derived from the parental cells. Recently, several studies have demonstrated that EVs can regulate many biological processes, such as cancer progression, the immune response, cell proliferation, cell migration and blood vessel tube formation. This regulation is achieved through the release and transport of EVs and the transfer of their parental cell-derived molecular cargo to recipient cells. This thereby influences various physiological and sometimes pathological functions within the target cells. While intensive investigation of EVs has focused on pathological processes, the involvement of EVs in normal wound healing is less clear; however, recent preliminarily investigations have produced some initial insights. This review will provide an overview of EVs and discuss the current literature regarding the role of EVs in wound healing, especially, their influence on coagulation, cell proliferation, migration, angiogenesis, collagen production and extracellular matrix remodelling. MDPI 2017-05-01 /pmc/articles/PMC5454869/ /pubmed/28468315 http://dx.doi.org/10.3390/ijms18050956 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Than, Uyen Thi Trang
Guanzon, Dominic
Leavesley, David
Parker, Tony
Association of Extracellular Membrane Vesicles with Cutaneous Wound Healing
title Association of Extracellular Membrane Vesicles with Cutaneous Wound Healing
title_full Association of Extracellular Membrane Vesicles with Cutaneous Wound Healing
title_fullStr Association of Extracellular Membrane Vesicles with Cutaneous Wound Healing
title_full_unstemmed Association of Extracellular Membrane Vesicles with Cutaneous Wound Healing
title_short Association of Extracellular Membrane Vesicles with Cutaneous Wound Healing
title_sort association of extracellular membrane vesicles with cutaneous wound healing
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5454869/
https://www.ncbi.nlm.nih.gov/pubmed/28468315
http://dx.doi.org/10.3390/ijms18050956
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