Valproic Acid Induces Endocytosis-Mediated Doxorubicin Internalization and Shows Synergistic Cytotoxic Effects in Hepatocellular Carcinoma Cells

Valproic acid (VPA), a well-known histone deacetylase (HDAC) inhibitor, is used as an anti-cancer drug for various cancers, but the synergistic anti-cancer effect of VPA and doxorubicin (DOX) combination treatment and its potential underlying mechanism in hepatocellular carcinoma (HCC) remain to be...

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Detalles Bibliográficos
Autores principales: Saha, Subbroto Kumar, Yin, Yingfu, Kim, Kyeongseok, Yang, Gwang-Mo, Abdal Dayem, Ahmed, Choi, Hye Yeon, Cho, Ssang-Goo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5454960/
https://www.ncbi.nlm.nih.gov/pubmed/28498322
http://dx.doi.org/10.3390/ijms18051048

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5454960/
https://www.ncbi.nlm.nih.gov/pubmed/28498322
http://dx.doi.org/10.3390/ijms18051048

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