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The Benefit of Benzodiazepine Reduction: Improving Sedation in Surgical Intensive Care
AIMS: Sedation, as it is often required in critical care, is associated with immobilization, prolonged ventilation, and increased morbidity. Most sedation protocols are based on benzodiazepines. The presented study analyzes the benefit of benzodiazepine-free sedation. METHODS: In 2008, 134 patients...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Medknow Publications & Media Pvt Ltd
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5455020/ https://www.ncbi.nlm.nih.gov/pubmed/28584430 http://dx.doi.org/10.4103/ijccm.IJCCM_67_17 |
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author | Schneider, Ralph Puetz, Andreas Vassiliou, Timon Wiesmann, Thomas Lewan, Ulrike Wulf, Hinnerk Bartsch, Detlef K. Rolfes, Caroline |
author_facet | Schneider, Ralph Puetz, Andreas Vassiliou, Timon Wiesmann, Thomas Lewan, Ulrike Wulf, Hinnerk Bartsch, Detlef K. Rolfes, Caroline |
author_sort | Schneider, Ralph |
collection | PubMed |
description | AIMS: Sedation, as it is often required in critical care, is associated with immobilization, prolonged ventilation, and increased morbidity. Most sedation protocols are based on benzodiazepines. The presented study analyzes the benefit of benzodiazepine-free sedation. METHODS: In 2008, 134 patients were treated according to a protocol using benzodiazepine and propofol (Group 1). In 2009, we introduced a new sedation strategy based on sufentanil, nonsteroidal anti-inflammatory drugs, neuroleptics, and antidepressants, which was applied in 140 consecutive patients (Group 2). Depth of sedation, duration of mechanical ventilation, duration of Intensive Care Unit, and hospital stay were analyzed. RESULTS: Group 1 had both a longer duration of deep sedation (18.7 ± 2.5 days vs. 12.6 ± 1.85 days, P = 0.031) and a longer duration of controlled ventilation (311, 35 ± 32.69 vs. 143, 96 ± 20.76 h, P < 0.0001) than Group 2. Ventilator days were more frequent in Group 1 (653, 66 ± 98.37 h vs. 478, 89 ± 68.92 h, P = 0.128). CONCLUSIONS: The benzodiazepine-free sedation protocol has been shown to significantly reduce depth of sedation and controlled ventilation. Additional evidence is needed to ascertain reduction of ventilator days which would not only be of benefit for the patient but also for the hospital Management. |
format | Online Article Text |
id | pubmed-5455020 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-54550202017-06-05 The Benefit of Benzodiazepine Reduction: Improving Sedation in Surgical Intensive Care Schneider, Ralph Puetz, Andreas Vassiliou, Timon Wiesmann, Thomas Lewan, Ulrike Wulf, Hinnerk Bartsch, Detlef K. Rolfes, Caroline Indian J Crit Care Med Research Article AIMS: Sedation, as it is often required in critical care, is associated with immobilization, prolonged ventilation, and increased morbidity. Most sedation protocols are based on benzodiazepines. The presented study analyzes the benefit of benzodiazepine-free sedation. METHODS: In 2008, 134 patients were treated according to a protocol using benzodiazepine and propofol (Group 1). In 2009, we introduced a new sedation strategy based on sufentanil, nonsteroidal anti-inflammatory drugs, neuroleptics, and antidepressants, which was applied in 140 consecutive patients (Group 2). Depth of sedation, duration of mechanical ventilation, duration of Intensive Care Unit, and hospital stay were analyzed. RESULTS: Group 1 had both a longer duration of deep sedation (18.7 ± 2.5 days vs. 12.6 ± 1.85 days, P = 0.031) and a longer duration of controlled ventilation (311, 35 ± 32.69 vs. 143, 96 ± 20.76 h, P < 0.0001) than Group 2. Ventilator days were more frequent in Group 1 (653, 66 ± 98.37 h vs. 478, 89 ± 68.92 h, P = 0.128). CONCLUSIONS: The benzodiazepine-free sedation protocol has been shown to significantly reduce depth of sedation and controlled ventilation. Additional evidence is needed to ascertain reduction of ventilator days which would not only be of benefit for the patient but also for the hospital Management. Medknow Publications & Media Pvt Ltd 2017-05 /pmc/articles/PMC5455020/ /pubmed/28584430 http://dx.doi.org/10.4103/ijccm.IJCCM_67_17 Text en Copyright: © 2017 Indian Journal of Critical Care Medicine http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
spellingShingle | Research Article Schneider, Ralph Puetz, Andreas Vassiliou, Timon Wiesmann, Thomas Lewan, Ulrike Wulf, Hinnerk Bartsch, Detlef K. Rolfes, Caroline The Benefit of Benzodiazepine Reduction: Improving Sedation in Surgical Intensive Care |
title | The Benefit of Benzodiazepine Reduction: Improving Sedation in Surgical Intensive Care |
title_full | The Benefit of Benzodiazepine Reduction: Improving Sedation in Surgical Intensive Care |
title_fullStr | The Benefit of Benzodiazepine Reduction: Improving Sedation in Surgical Intensive Care |
title_full_unstemmed | The Benefit of Benzodiazepine Reduction: Improving Sedation in Surgical Intensive Care |
title_short | The Benefit of Benzodiazepine Reduction: Improving Sedation in Surgical Intensive Care |
title_sort | benefit of benzodiazepine reduction: improving sedation in surgical intensive care |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5455020/ https://www.ncbi.nlm.nih.gov/pubmed/28584430 http://dx.doi.org/10.4103/ijccm.IJCCM_67_17 |
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