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Active case-finding for tuberculosis by mobile teams in Myanmar: yield and treatment outcomes

BACKGROUND: Since 2005, the Myanmar National Tuberculosis Programme (NTP) has been implementing active case finding (ACF) activities involving mobile teams in hard-to-reach areas. This study revealed the contribution of mobile team activities to total tuberculosis (TB) case detection, characteristic...

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Autores principales: Myint, Ohnmar, Saw, Saw, Isaakidis, Petros, Khogali, Mohammed, Reid, Anthony, Hoa, Nguyen Binh, Kyaw, Thi Thi, Zaw, Ko Ko, Khaing, Tin Mi Mi, Aung, Si Thu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5455111/
https://www.ncbi.nlm.nih.gov/pubmed/28571575
http://dx.doi.org/10.1186/s40249-017-0291-5
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author Myint, Ohnmar
Saw, Saw
Isaakidis, Petros
Khogali, Mohammed
Reid, Anthony
Hoa, Nguyen Binh
Kyaw, Thi Thi
Zaw, Ko Ko
Khaing, Tin Mi Mi
Aung, Si Thu
author_facet Myint, Ohnmar
Saw, Saw
Isaakidis, Petros
Khogali, Mohammed
Reid, Anthony
Hoa, Nguyen Binh
Kyaw, Thi Thi
Zaw, Ko Ko
Khaing, Tin Mi Mi
Aung, Si Thu
author_sort Myint, Ohnmar
collection PubMed
description BACKGROUND: Since 2005, the Myanmar National Tuberculosis Programme (NTP) has been implementing active case finding (ACF) activities involving mobile teams in hard-to-reach areas. This study revealed the contribution of mobile team activities to total tuberculosis (TB) case detection, characteristics of TB patients detected by mobile teams and their treatment outcomes. METHODS: This was a descriptive study using routine programme data between October 2014 and December 2014. Mobile team activities were a one-stop service and included portable digital chest radiography (CXR) and microscopy of two sputum samples. The algorithm of the case detection included screening patients by symptoms, then by CXR followed by sputum microscopy for confirmation. Diagnosed patients were started on treatment and followed until a final outcome was ascertained. RESULTS: A total of 9 349 people with symptoms suggestive of TB were screened by CXR, with an uptake of 96.6%. Of those who were meant to undergo sputum smear microscopy, 51.4% had sputum examinations. Finally, 504 TB patients were identified by the mobile teams and the overall contribution to total TB case detection in the respective townships was 25.3%. Among total cases examined by microscopy, 6.4% were sputum smear positive TB. Treatment success rate was high as 91.8% in study townships compared to national rate 85% (2014 cohort). CONCLUSIONS: This study confirmed the feasibility and acceptability of ACF by mobile teams in hard-to-reach contexts, especially when equipped with portable, digital CXR machines that provided immediate results. However, the follow-up process of sputum examination created a significant barrier to confirmation of the diagnosis. In order to optimize the ACF through mobile team activity, future ACF activities were needed to be strengthened one stop service including molecular diagnostics or provision of sputum cups to all presumptive TB cases prior to CXR and testing if CXR suggestive of TB. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s40249-017-0291-5) contains supplementary material, which is available to authorized users.
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spelling pubmed-54551112017-06-06 Active case-finding for tuberculosis by mobile teams in Myanmar: yield and treatment outcomes Myint, Ohnmar Saw, Saw Isaakidis, Petros Khogali, Mohammed Reid, Anthony Hoa, Nguyen Binh Kyaw, Thi Thi Zaw, Ko Ko Khaing, Tin Mi Mi Aung, Si Thu Infect Dis Poverty Research Article BACKGROUND: Since 2005, the Myanmar National Tuberculosis Programme (NTP) has been implementing active case finding (ACF) activities involving mobile teams in hard-to-reach areas. This study revealed the contribution of mobile team activities to total tuberculosis (TB) case detection, characteristics of TB patients detected by mobile teams and their treatment outcomes. METHODS: This was a descriptive study using routine programme data between October 2014 and December 2014. Mobile team activities were a one-stop service and included portable digital chest radiography (CXR) and microscopy of two sputum samples. The algorithm of the case detection included screening patients by symptoms, then by CXR followed by sputum microscopy for confirmation. Diagnosed patients were started on treatment and followed until a final outcome was ascertained. RESULTS: A total of 9 349 people with symptoms suggestive of TB were screened by CXR, with an uptake of 96.6%. Of those who were meant to undergo sputum smear microscopy, 51.4% had sputum examinations. Finally, 504 TB patients were identified by the mobile teams and the overall contribution to total TB case detection in the respective townships was 25.3%. Among total cases examined by microscopy, 6.4% were sputum smear positive TB. Treatment success rate was high as 91.8% in study townships compared to national rate 85% (2014 cohort). CONCLUSIONS: This study confirmed the feasibility and acceptability of ACF by mobile teams in hard-to-reach contexts, especially when equipped with portable, digital CXR machines that provided immediate results. However, the follow-up process of sputum examination created a significant barrier to confirmation of the diagnosis. In order to optimize the ACF through mobile team activity, future ACF activities were needed to be strengthened one stop service including molecular diagnostics or provision of sputum cups to all presumptive TB cases prior to CXR and testing if CXR suggestive of TB. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s40249-017-0291-5) contains supplementary material, which is available to authorized users. BioMed Central 2017-06-02 /pmc/articles/PMC5455111/ /pubmed/28571575 http://dx.doi.org/10.1186/s40249-017-0291-5 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Myint, Ohnmar
Saw, Saw
Isaakidis, Petros
Khogali, Mohammed
Reid, Anthony
Hoa, Nguyen Binh
Kyaw, Thi Thi
Zaw, Ko Ko
Khaing, Tin Mi Mi
Aung, Si Thu
Active case-finding for tuberculosis by mobile teams in Myanmar: yield and treatment outcomes
title Active case-finding for tuberculosis by mobile teams in Myanmar: yield and treatment outcomes
title_full Active case-finding for tuberculosis by mobile teams in Myanmar: yield and treatment outcomes
title_fullStr Active case-finding for tuberculosis by mobile teams in Myanmar: yield and treatment outcomes
title_full_unstemmed Active case-finding for tuberculosis by mobile teams in Myanmar: yield and treatment outcomes
title_short Active case-finding for tuberculosis by mobile teams in Myanmar: yield and treatment outcomes
title_sort active case-finding for tuberculosis by mobile teams in myanmar: yield and treatment outcomes
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5455111/
https://www.ncbi.nlm.nih.gov/pubmed/28571575
http://dx.doi.org/10.1186/s40249-017-0291-5
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