Sphingosine 1-phosphate receptor 3 and RhoA signaling mediate inflammatory gene expression in astrocytes

BACKGROUND: Sphingosine 1-phosphate (S1P) signals through G protein-coupled receptors to elicit a wide range of cellular responses. In CNS injury and disease, the blood-brain barrier is compromised, causing leakage of S1P from blood into the brain. S1P can also be locally generated through the enzym...

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Detalles Bibliográficos
Autores principales: Dusaban, Stephanie S., Chun, Jerold, Rosen, Hugh, Purcell, Nicole H., Brown, Joan Heller
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5455202/
https://www.ncbi.nlm.nih.gov/pubmed/28577576
http://dx.doi.org/10.1186/s12974-017-0882-x

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