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Complement C5a-C5aR1 signalling drives skeletal muscle macrophage recruitment in the hSOD1(G93A) mouse model of amyotrophic lateral sclerosis

BACKGROUND: The terminal pathway of the innate immune complement system is implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS). Terminal complement activation leads to generation of C5a, which through its receptor, C5aR1, drives immune cell recruitment and activation. Importantly,...

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Detalles Bibliográficos
Autores principales:	Wang, Haitao A., Lee, John D., Lee, Kah Meng, Woodruff, Trent M., Noakes, Peter G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5455206/ https://www.ncbi.nlm.nih.gov/pubmed/28571586 http://dx.doi.org/10.1186/s13395-017-0128-8

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