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Mixed leukocyte cell-derived chemotaxin 2 and amyloid A renal amyloidosis in a Kazakh-German patient

Leukocyte cell-derived chemotaxin 2 (LECT2)-related amyloidosis (ALECT2) constitutes a subtype of systemic amyloidosis affecting the kidney. This is the first case describing mixed ALECT2 and Amyloid A renal amyloidosis in a Kazakh-German patient. Genetic analysis shows a polymorphism in the LECT2 g...

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Autores principales: Gödecke, Vega A., Röcken, Christoph, Steinmüller-Magin, Lars, Nadrowitz, Felix, Fleig, Susanne V., Haller, Hermann, Wagner, Annette D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5455215/
https://www.ncbi.nlm.nih.gov/pubmed/28584627
http://dx.doi.org/10.1093/ckj/sfw147
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author Gödecke, Vega A.
Röcken, Christoph
Steinmüller-Magin, Lars
Nadrowitz, Felix
Fleig, Susanne V.
Haller, Hermann
Wagner, Annette D.
author_facet Gödecke, Vega A.
Röcken, Christoph
Steinmüller-Magin, Lars
Nadrowitz, Felix
Fleig, Susanne V.
Haller, Hermann
Wagner, Annette D.
author_sort Gödecke, Vega A.
collection PubMed
description Leukocyte cell-derived chemotaxin 2 (LECT2)-related amyloidosis (ALECT2) constitutes a subtype of systemic amyloidosis affecting the kidney. This is the first case describing mixed ALECT2 and Amyloid A renal amyloidosis in a Kazakh-German patient. Genetic analysis shows a polymorphism in the LECT2 gene and a homozygous mutation in the SAA1 gene. Notably, our patient has a body mass index of 61 kg/m(2) and a pathological glucose tolerance test. ALECT2 was found in certain ethnic groups with a high incidence of diabetes. In our case, morbid obesity may have played a significant role in clinical manifestation of ALECT2 amyloidosis.
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spelling pubmed-54552152017-06-05 Mixed leukocyte cell-derived chemotaxin 2 and amyloid A renal amyloidosis in a Kazakh-German patient Gödecke, Vega A. Röcken, Christoph Steinmüller-Magin, Lars Nadrowitz, Felix Fleig, Susanne V. Haller, Hermann Wagner, Annette D. Clin Kidney J Rare Diseases Leukocyte cell-derived chemotaxin 2 (LECT2)-related amyloidosis (ALECT2) constitutes a subtype of systemic amyloidosis affecting the kidney. This is the first case describing mixed ALECT2 and Amyloid A renal amyloidosis in a Kazakh-German patient. Genetic analysis shows a polymorphism in the LECT2 gene and a homozygous mutation in the SAA1 gene. Notably, our patient has a body mass index of 61 kg/m(2) and a pathological glucose tolerance test. ALECT2 was found in certain ethnic groups with a high incidence of diabetes. In our case, morbid obesity may have played a significant role in clinical manifestation of ALECT2 amyloidosis. Oxford University Press 2017-04 2017-02-03 /pmc/articles/PMC5455215/ /pubmed/28584627 http://dx.doi.org/10.1093/ckj/sfw147 Text en © The Author 2017. Published by Oxford University Press on behalf of ERA-EDTA. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Rare Diseases
Gödecke, Vega A.
Röcken, Christoph
Steinmüller-Magin, Lars
Nadrowitz, Felix
Fleig, Susanne V.
Haller, Hermann
Wagner, Annette D.
Mixed leukocyte cell-derived chemotaxin 2 and amyloid A renal amyloidosis in a Kazakh-German patient
title Mixed leukocyte cell-derived chemotaxin 2 and amyloid A renal amyloidosis in a Kazakh-German patient
title_full Mixed leukocyte cell-derived chemotaxin 2 and amyloid A renal amyloidosis in a Kazakh-German patient
title_fullStr Mixed leukocyte cell-derived chemotaxin 2 and amyloid A renal amyloidosis in a Kazakh-German patient
title_full_unstemmed Mixed leukocyte cell-derived chemotaxin 2 and amyloid A renal amyloidosis in a Kazakh-German patient
title_short Mixed leukocyte cell-derived chemotaxin 2 and amyloid A renal amyloidosis in a Kazakh-German patient
title_sort mixed leukocyte cell-derived chemotaxin 2 and amyloid a renal amyloidosis in a kazakh-german patient
topic Rare Diseases
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5455215/
https://www.ncbi.nlm.nih.gov/pubmed/28584627
http://dx.doi.org/10.1093/ckj/sfw147
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