Quercetin reduces hydroxyurea induced cytotoxicity in immortalized mouse aortic endothelial cells

BACKGROUND: Chronic inflammation is a characteristic of sickle cell disease (SCD), and is invariably associated with vascular endothelial injury. Hydroxyurea (HU), a naturally cytotoxic chemotherapeutic agent, is the only FDA drug approved for SCD, and is therefore naturally cytotoxic. Quercetin (QC...

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Detalles Bibliográficos
Autores principales: Kiser, Zachary M., McGee, Monica D.M., Wright, Racquel J., Quarshie, Alexander, Newman, Gale W., Randall, Karen R., Stiles, Jonathan K., Driss, Adel, Hibbert, Jacqueline M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2017
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5455336/
https://www.ncbi.nlm.nih.gov/pubmed/28584711
http://dx.doi.org/10.7717/peerj.3376

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