Sugar-Responsive Pseudopolyrotaxane Composed of Phenylboronic Acid-Modified Polyethylene Glycol and γ-Cyclodextrin

We have designed a sugar-responsive pseudopolyrotaxane (PPRX) by combining phenylboronic acid-modified polyethylene glycol (PBA–PEG) and γ-cyclodextrin. Phenylboronic acid (PBA) was used as a sugar-recognition motif in the PPRX because PBA reacts with a diol portion of the sugar molecule and forms a...

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Detalles Bibliográficos
Autores principales: Seki, Tomohiro, Namiki, Misato, Egawa, Yuya, Miki, Ryotaro, Juni, Kazuhiko, Seki, Toshinobu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5455434/
https://www.ncbi.nlm.nih.gov/pubmed/28788004
http://dx.doi.org/10.3390/ma8031341
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author Seki, Tomohiro
Namiki, Misato
Egawa, Yuya
Miki, Ryotaro
Juni, Kazuhiko
Seki, Toshinobu
author_facet Seki, Tomohiro
Namiki, Misato
Egawa, Yuya
Miki, Ryotaro
Juni, Kazuhiko
Seki, Toshinobu
author_sort Seki, Tomohiro
collection PubMed
description We have designed a sugar-responsive pseudopolyrotaxane (PPRX) by combining phenylboronic acid-modified polyethylene glycol (PBA–PEG) and γ-cyclodextrin. Phenylboronic acid (PBA) was used as a sugar-recognition motif in the PPRX because PBA reacts with a diol portion of the sugar molecule and forms a cyclic ester. When D-fructose or D-glucose was added to a suspension of PPRX, PPRX disintegrated, depending on the concentration of the sugars. Interestingly, catechol does not show a response although catechol has a high affinity for PBA. We analyzed the response mechanism of PPRX by considering equilibria.
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spelling pubmed-54554342017-07-28 Sugar-Responsive Pseudopolyrotaxane Composed of Phenylboronic Acid-Modified Polyethylene Glycol and γ-Cyclodextrin Seki, Tomohiro Namiki, Misato Egawa, Yuya Miki, Ryotaro Juni, Kazuhiko Seki, Toshinobu Materials (Basel) Communication We have designed a sugar-responsive pseudopolyrotaxane (PPRX) by combining phenylboronic acid-modified polyethylene glycol (PBA–PEG) and γ-cyclodextrin. Phenylboronic acid (PBA) was used as a sugar-recognition motif in the PPRX because PBA reacts with a diol portion of the sugar molecule and forms a cyclic ester. When D-fructose or D-glucose was added to a suspension of PPRX, PPRX disintegrated, depending on the concentration of the sugars. Interestingly, catechol does not show a response although catechol has a high affinity for PBA. We analyzed the response mechanism of PPRX by considering equilibria. MDPI 2015-03-20 /pmc/articles/PMC5455434/ /pubmed/28788004 http://dx.doi.org/10.3390/ma8031341 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Seki, Tomohiro
Namiki, Misato
Egawa, Yuya
Miki, Ryotaro
Juni, Kazuhiko
Seki, Toshinobu
Sugar-Responsive Pseudopolyrotaxane Composed of Phenylboronic Acid-Modified Polyethylene Glycol and γ-Cyclodextrin
title Sugar-Responsive Pseudopolyrotaxane Composed of Phenylboronic Acid-Modified Polyethylene Glycol and γ-Cyclodextrin
title_full Sugar-Responsive Pseudopolyrotaxane Composed of Phenylboronic Acid-Modified Polyethylene Glycol and γ-Cyclodextrin
title_fullStr Sugar-Responsive Pseudopolyrotaxane Composed of Phenylboronic Acid-Modified Polyethylene Glycol and γ-Cyclodextrin
title_full_unstemmed Sugar-Responsive Pseudopolyrotaxane Composed of Phenylboronic Acid-Modified Polyethylene Glycol and γ-Cyclodextrin
title_short Sugar-Responsive Pseudopolyrotaxane Composed of Phenylboronic Acid-Modified Polyethylene Glycol and γ-Cyclodextrin
title_sort sugar-responsive pseudopolyrotaxane composed of phenylboronic acid-modified polyethylene glycol and γ-cyclodextrin
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5455434/
https://www.ncbi.nlm.nih.gov/pubmed/28788004
http://dx.doi.org/10.3390/ma8031341
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