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Vasectomy and Prostate Cancer Risk in the European Prospective Investigation Into Cancer and Nutrition (EPIC)
PURPOSE: Vasectomy is a commonly used form of male sterilization, and some studies have suggested that it may be associated with an increased risk of prostate cancer, including more aggressive forms of the disease. We investigated the prospective association of vasectomy with prostate cancer in a la...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society of Clinical Oncology
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5455458/ https://www.ncbi.nlm.nih.gov/pubmed/28375714 http://dx.doi.org/10.1200/JCO.2016.70.0062 |
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author | Smith, Karl Byrne, Castaño, Jose Maria Chirlaque, Maria Dolores Lilja, Hans Agudo, Antonio Ardanaz, Eva Rodríguez-Barranco, Miguel Boeing, Heiner Kaaks, Rudolf Khaw, Kay-Tee Larrañaga, Nerea Navarro, Carmen Olsen, Anja Overvad, Kim Perez-Cornago, Aurora Rohrmann, Sabine Sánchez, Maria José Tjønneland, Anne Tsilidis, Konstantinos K. Johansson, Mattias Riboli, Elio Key, Timothy J. Travis, Ruth C. |
author_facet | Smith, Karl Byrne, Castaño, Jose Maria Chirlaque, Maria Dolores Lilja, Hans Agudo, Antonio Ardanaz, Eva Rodríguez-Barranco, Miguel Boeing, Heiner Kaaks, Rudolf Khaw, Kay-Tee Larrañaga, Nerea Navarro, Carmen Olsen, Anja Overvad, Kim Perez-Cornago, Aurora Rohrmann, Sabine Sánchez, Maria José Tjønneland, Anne Tsilidis, Konstantinos K. Johansson, Mattias Riboli, Elio Key, Timothy J. Travis, Ruth C. |
author_sort | Smith, Karl |
collection | PubMed |
description | PURPOSE: Vasectomy is a commonly used form of male sterilization, and some studies have suggested that it may be associated with an increased risk of prostate cancer, including more aggressive forms of the disease. We investigated the prospective association of vasectomy with prostate cancer in a large European cohort, with a focus on high-grade and advanced-stage tumors, and death due to prostate cancer. PATIENTS AND METHODS: A total of 84,753 men from the European Prospective Investigation into Cancer and Nutrition (EPIC), aged 35 to 79 years, provided information on vasectomy status (15% with vasectomy) at recruitment and were followed for incidence of prostate cancer and death. We estimated the association of vasectomy with prostate cancer risk overall, by tumor subtype, and for death due to prostate cancer, using multivariable-adjusted Cox proportional hazards models. RESULTS: During an average follow-up of 15.4 years, 4,377 men were diagnosed with prostate cancer, including 641 who had undergone a vasectomy. Vasectomy was not associated with prostate cancer risk (hazard ratio [HR], 1.05; 95% CI, 0.96 to 1.15), and no evidence for heterogeneity in the association was observed by stage of disease or years since vasectomy. There was some evidence of heterogeneity by tumor grade (P = .02), with an increased risk for low-intermediate grade (HR, 1.14; 95% CI, 1.01 to 1.29) but not high-grade prostate cancer (HR, 0.83; 95% CI, 0.64 to 1.07). Vasectomy was not associated with death due to prostate cancer (HR, 0.88; 95% CI, 0.68 to 1.12). CONCLUSION: These findings from a large European prospective study show no elevated risk for overall, high-grade or advanced-stage prostate cancer, or death due to prostate cancer in men who have undergone a vasectomy compared with men who have not. |
format | Online Article Text |
id | pubmed-5455458 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | American Society of Clinical Oncology |
record_format | MEDLINE/PubMed |
spelling | pubmed-54554582017-10-30 Vasectomy and Prostate Cancer Risk in the European Prospective Investigation Into Cancer and Nutrition (EPIC) Smith, Karl Byrne, Castaño, Jose Maria Chirlaque, Maria Dolores Lilja, Hans Agudo, Antonio Ardanaz, Eva Rodríguez-Barranco, Miguel Boeing, Heiner Kaaks, Rudolf Khaw, Kay-Tee Larrañaga, Nerea Navarro, Carmen Olsen, Anja Overvad, Kim Perez-Cornago, Aurora Rohrmann, Sabine Sánchez, Maria José Tjønneland, Anne Tsilidis, Konstantinos K. Johansson, Mattias Riboli, Elio Key, Timothy J. Travis, Ruth C. J Clin Oncol ORIGINAL REPORTS PURPOSE: Vasectomy is a commonly used form of male sterilization, and some studies have suggested that it may be associated with an increased risk of prostate cancer, including more aggressive forms of the disease. We investigated the prospective association of vasectomy with prostate cancer in a large European cohort, with a focus on high-grade and advanced-stage tumors, and death due to prostate cancer. PATIENTS AND METHODS: A total of 84,753 men from the European Prospective Investigation into Cancer and Nutrition (EPIC), aged 35 to 79 years, provided information on vasectomy status (15% with vasectomy) at recruitment and were followed for incidence of prostate cancer and death. We estimated the association of vasectomy with prostate cancer risk overall, by tumor subtype, and for death due to prostate cancer, using multivariable-adjusted Cox proportional hazards models. RESULTS: During an average follow-up of 15.4 years, 4,377 men were diagnosed with prostate cancer, including 641 who had undergone a vasectomy. Vasectomy was not associated with prostate cancer risk (hazard ratio [HR], 1.05; 95% CI, 0.96 to 1.15), and no evidence for heterogeneity in the association was observed by stage of disease or years since vasectomy. There was some evidence of heterogeneity by tumor grade (P = .02), with an increased risk for low-intermediate grade (HR, 1.14; 95% CI, 1.01 to 1.29) but not high-grade prostate cancer (HR, 0.83; 95% CI, 0.64 to 1.07). Vasectomy was not associated with death due to prostate cancer (HR, 0.88; 95% CI, 0.68 to 1.12). CONCLUSION: These findings from a large European prospective study show no elevated risk for overall, high-grade or advanced-stage prostate cancer, or death due to prostate cancer in men who have undergone a vasectomy compared with men who have not. American Society of Clinical Oncology 2017-04-20 2017-03-06 /pmc/articles/PMC5455458/ /pubmed/28375714 http://dx.doi.org/10.1200/JCO.2016.70.0062 Text en © 2017 by American Society of Clinical Oncology http://creativecommons.org/licenses/by/4.0/ Licensed under the Creative Commons Attribution 4.0 License: http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | ORIGINAL REPORTS Smith, Karl Byrne, Castaño, Jose Maria Chirlaque, Maria Dolores Lilja, Hans Agudo, Antonio Ardanaz, Eva Rodríguez-Barranco, Miguel Boeing, Heiner Kaaks, Rudolf Khaw, Kay-Tee Larrañaga, Nerea Navarro, Carmen Olsen, Anja Overvad, Kim Perez-Cornago, Aurora Rohrmann, Sabine Sánchez, Maria José Tjønneland, Anne Tsilidis, Konstantinos K. Johansson, Mattias Riboli, Elio Key, Timothy J. Travis, Ruth C. Vasectomy and Prostate Cancer Risk in the European Prospective Investigation Into Cancer and Nutrition (EPIC) |
title | Vasectomy and Prostate Cancer Risk in the European Prospective Investigation Into Cancer and Nutrition (EPIC) |
title_full | Vasectomy and Prostate Cancer Risk in the European Prospective Investigation Into Cancer and Nutrition (EPIC) |
title_fullStr | Vasectomy and Prostate Cancer Risk in the European Prospective Investigation Into Cancer and Nutrition (EPIC) |
title_full_unstemmed | Vasectomy and Prostate Cancer Risk in the European Prospective Investigation Into Cancer and Nutrition (EPIC) |
title_short | Vasectomy and Prostate Cancer Risk in the European Prospective Investigation Into Cancer and Nutrition (EPIC) |
title_sort | vasectomy and prostate cancer risk in the european prospective investigation into cancer and nutrition (epic) |
topic | ORIGINAL REPORTS |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5455458/ https://www.ncbi.nlm.nih.gov/pubmed/28375714 http://dx.doi.org/10.1200/JCO.2016.70.0062 |
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