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Mechanical Properties and Cytocompatibility Improvement of Vertebroplasty PMMA Bone Cements by Incorporating Mineralized Collagen

Polymethyl methacrylate (PMMA) bone cement is a commonly used bone adhesive and filling material in percutaneous vertebroplasty and percutaneous kyphoplasty surgeries. However, PMMA bone cements have been reported to cause some severe complications, such as secondary fracture of adjacent vertebral b...

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Autores principales: Jiang, Hong-Jiang, Xu, Jin, Qiu, Zhi-Ye, Ma, Xin-Long, Zhang, Zi-Qiang, Tan, Xun-Xiang, Cui, Yun, Cui, Fu-Zhai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5455539/
http://dx.doi.org/10.3390/ma8052616
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author Jiang, Hong-Jiang
Xu, Jin
Qiu, Zhi-Ye
Ma, Xin-Long
Zhang, Zi-Qiang
Tan, Xun-Xiang
Cui, Yun
Cui, Fu-Zhai
author_facet Jiang, Hong-Jiang
Xu, Jin
Qiu, Zhi-Ye
Ma, Xin-Long
Zhang, Zi-Qiang
Tan, Xun-Xiang
Cui, Yun
Cui, Fu-Zhai
author_sort Jiang, Hong-Jiang
collection PubMed
description Polymethyl methacrylate (PMMA) bone cement is a commonly used bone adhesive and filling material in percutaneous vertebroplasty and percutaneous kyphoplasty surgeries. However, PMMA bone cements have been reported to cause some severe complications, such as secondary fracture of adjacent vertebral bodies, and loosening or even dislodgement of the set PMMA bone cement, due to the over-high elastic modulus and poor osteointegration ability of the PMMA. In this study, mineralized collagen (MC) with biomimetic microstructure and good osteogenic activity was added to commercially available PMMA bone cement products, in order to improve both the mechanical properties and the cytocompatibility. As the compressive strength of the modified bone cements remained well, the compressive elastic modulus could be significantly down-regulated by the MC, so as to reduce the pressure on the adjacent vertebral bodies. Meanwhile, the adhesion and proliferation of pre-osteoblasts on the modified bone cements were improved compared with cells on those unmodified, such result is beneficial for a good osteointegration formation between the bone cement and the host bone tissue in clinical applications. Moreover, the modification of the PMMA bone cements by adding MC did not significantly influence the injectability and processing times of the cement.
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spelling pubmed-54555392017-07-28 Mechanical Properties and Cytocompatibility Improvement of Vertebroplasty PMMA Bone Cements by Incorporating Mineralized Collagen Jiang, Hong-Jiang Xu, Jin Qiu, Zhi-Ye Ma, Xin-Long Zhang, Zi-Qiang Tan, Xun-Xiang Cui, Yun Cui, Fu-Zhai Materials (Basel) Article Polymethyl methacrylate (PMMA) bone cement is a commonly used bone adhesive and filling material in percutaneous vertebroplasty and percutaneous kyphoplasty surgeries. However, PMMA bone cements have been reported to cause some severe complications, such as secondary fracture of adjacent vertebral bodies, and loosening or even dislodgement of the set PMMA bone cement, due to the over-high elastic modulus and poor osteointegration ability of the PMMA. In this study, mineralized collagen (MC) with biomimetic microstructure and good osteogenic activity was added to commercially available PMMA bone cement products, in order to improve both the mechanical properties and the cytocompatibility. As the compressive strength of the modified bone cements remained well, the compressive elastic modulus could be significantly down-regulated by the MC, so as to reduce the pressure on the adjacent vertebral bodies. Meanwhile, the adhesion and proliferation of pre-osteoblasts on the modified bone cements were improved compared with cells on those unmodified, such result is beneficial for a good osteointegration formation between the bone cement and the host bone tissue in clinical applications. Moreover, the modification of the PMMA bone cements by adding MC did not significantly influence the injectability and processing times of the cement. MDPI 2015-05-13 /pmc/articles/PMC5455539/ http://dx.doi.org/10.3390/ma8052616 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Jiang, Hong-Jiang
Xu, Jin
Qiu, Zhi-Ye
Ma, Xin-Long
Zhang, Zi-Qiang
Tan, Xun-Xiang
Cui, Yun
Cui, Fu-Zhai
Mechanical Properties and Cytocompatibility Improvement of Vertebroplasty PMMA Bone Cements by Incorporating Mineralized Collagen
title Mechanical Properties and Cytocompatibility Improvement of Vertebroplasty PMMA Bone Cements by Incorporating Mineralized Collagen
title_full Mechanical Properties and Cytocompatibility Improvement of Vertebroplasty PMMA Bone Cements by Incorporating Mineralized Collagen
title_fullStr Mechanical Properties and Cytocompatibility Improvement of Vertebroplasty PMMA Bone Cements by Incorporating Mineralized Collagen
title_full_unstemmed Mechanical Properties and Cytocompatibility Improvement of Vertebroplasty PMMA Bone Cements by Incorporating Mineralized Collagen
title_short Mechanical Properties and Cytocompatibility Improvement of Vertebroplasty PMMA Bone Cements by Incorporating Mineralized Collagen
title_sort mechanical properties and cytocompatibility improvement of vertebroplasty pmma bone cements by incorporating mineralized collagen
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5455539/
http://dx.doi.org/10.3390/ma8052616
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