Gene-dosage effects in Down syndrome and trisomic mouse models

The abnormalities found in human Down syndrome (trisomy 21) have been thought to result from increased expression of genes on chromosome 21 because of their higher gene dosage. Now, several groups have shown this to be generally the case, but some inter-individual variability and other exceptions we...

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Detalles Bibliográficos
Autor principal: Gardiner, Katheleen
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2004
Materias:
Minireview
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC545589/
https://www.ncbi.nlm.nih.gov/pubmed/15461808
http://dx.doi.org/10.1186/gb-2004-5-10-244
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author Gardiner, Katheleen
author_facet Gardiner, Katheleen
author_sort Gardiner, Katheleen
collection PubMed
description The abnormalities found in human Down syndrome (trisomy 21) have been thought to result from increased expression of genes on chromosome 21 because of their higher gene dosage. Now, several groups have shown this to be generally the case, but some inter-individual variability and other exceptions were found.
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spelling pubmed-5455892005-01-26 Gene-dosage effects in Down syndrome and trisomic mouse models Gardiner, Katheleen Genome Biol Minireview The abnormalities found in human Down syndrome (trisomy 21) have been thought to result from increased expression of genes on chromosome 21 because of their higher gene dosage. Now, several groups have shown this to be generally the case, but some inter-individual variability and other exceptions were found. BioMed Central 2004 2004-09-30 /pmc/articles/PMC545589/ /pubmed/15461808 http://dx.doi.org/10.1186/gb-2004-5-10-244 Text en Copyright © 2004 BioMed Central Ltd
spellingShingle Minireview
Gardiner, Katheleen
Gene-dosage effects in Down syndrome and trisomic mouse models
title Gene-dosage effects in Down syndrome and trisomic mouse models
title_full Gene-dosage effects in Down syndrome and trisomic mouse models
title_fullStr Gene-dosage effects in Down syndrome and trisomic mouse models
title_full_unstemmed Gene-dosage effects in Down syndrome and trisomic mouse models
title_short Gene-dosage effects in Down syndrome and trisomic mouse models
title_sort gene-dosage effects in down syndrome and trisomic mouse models
topic Minireview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC545589/
https://www.ncbi.nlm.nih.gov/pubmed/15461808
http://dx.doi.org/10.1186/gb-2004-5-10-244
work_keys_str_mv AT gardinerkatheleen genedosageeffectsindownsyndromeandtrisomicmousemodels

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