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Lessons learnt from human papillomavirus (HPV) vaccination in 45 low- and middle-income countries
OBJECTIVE: To synthesise lessons learnt and determinants of success from human papillomavirus (HPV) vaccine demonstration projects and national programmes in low- and middle-income countries (LAMICs). METHODS: Interviews were conducted with 56 key informants. A systematic literature review identifie...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5456063/ https://www.ncbi.nlm.nih.gov/pubmed/28575074 http://dx.doi.org/10.1371/journal.pone.0177773 |
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author | Gallagher, Katherine E. Howard, Natasha Kabakama, Severin Mounier-Jack, Sandra Griffiths, Ulla K. Feletto, Marta Burchett, Helen E. D. LaMontagne, D. Scott Watson-Jones, Deborah |
author_facet | Gallagher, Katherine E. Howard, Natasha Kabakama, Severin Mounier-Jack, Sandra Griffiths, Ulla K. Feletto, Marta Burchett, Helen E. D. LaMontagne, D. Scott Watson-Jones, Deborah |
author_sort | Gallagher, Katherine E. |
collection | PubMed |
description | OBJECTIVE: To synthesise lessons learnt and determinants of success from human papillomavirus (HPV) vaccine demonstration projects and national programmes in low- and middle-income countries (LAMICs). METHODS: Interviews were conducted with 56 key informants. A systematic literature review identified 2936 abstracts from five databases; after screening 61 full texts were included. Unpublished literature, including evaluation reports, was solicited from country representatives; 188 documents were received. A data extraction tool and interview topic guide outlining key areas of inquiry were informed by World Health Organization guidelines for new vaccine introduction. Results were synthesised thematically. RESULTS: Data were analysed from 12 national programmes and 66 demonstration projects in 46 countries. Among demonstration projects, 30 were supported by the GARDASIL(®) Access Program, 20 by Gavi, four by PATH and 12 by other means. School-based vaccine delivery supplemented with health facility-based delivery for out-of-school girls attained high coverage. There were limited data on facility-only strategies and little evaluation of strategies to reach out-of-school girls. Early engagement of teachers as partners in social mobilisation, consent, vaccination day coordination, follow-up of non-completers and adverse events was considered invaluable. Micro-planning using school/ facility registers most effectively enumerated target populations; other estimates proved inaccurate, leading to vaccine under- or over-estimation. Refresher training on adverse events and safe injection procedures was usually necessary. CONCLUSION: Considerable experience in HPV vaccine delivery in LAMICs is available. Lessons are generally consistent across countries and dissemination of these could improve HPV vaccine introduction. |
format | Online Article Text |
id | pubmed-5456063 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-54560632017-06-12 Lessons learnt from human papillomavirus (HPV) vaccination in 45 low- and middle-income countries Gallagher, Katherine E. Howard, Natasha Kabakama, Severin Mounier-Jack, Sandra Griffiths, Ulla K. Feletto, Marta Burchett, Helen E. D. LaMontagne, D. Scott Watson-Jones, Deborah PLoS One Research Article OBJECTIVE: To synthesise lessons learnt and determinants of success from human papillomavirus (HPV) vaccine demonstration projects and national programmes in low- and middle-income countries (LAMICs). METHODS: Interviews were conducted with 56 key informants. A systematic literature review identified 2936 abstracts from five databases; after screening 61 full texts were included. Unpublished literature, including evaluation reports, was solicited from country representatives; 188 documents were received. A data extraction tool and interview topic guide outlining key areas of inquiry were informed by World Health Organization guidelines for new vaccine introduction. Results were synthesised thematically. RESULTS: Data were analysed from 12 national programmes and 66 demonstration projects in 46 countries. Among demonstration projects, 30 were supported by the GARDASIL(®) Access Program, 20 by Gavi, four by PATH and 12 by other means. School-based vaccine delivery supplemented with health facility-based delivery for out-of-school girls attained high coverage. There were limited data on facility-only strategies and little evaluation of strategies to reach out-of-school girls. Early engagement of teachers as partners in social mobilisation, consent, vaccination day coordination, follow-up of non-completers and adverse events was considered invaluable. Micro-planning using school/ facility registers most effectively enumerated target populations; other estimates proved inaccurate, leading to vaccine under- or over-estimation. Refresher training on adverse events and safe injection procedures was usually necessary. CONCLUSION: Considerable experience in HPV vaccine delivery in LAMICs is available. Lessons are generally consistent across countries and dissemination of these could improve HPV vaccine introduction. Public Library of Science 2017-06-02 /pmc/articles/PMC5456063/ /pubmed/28575074 http://dx.doi.org/10.1371/journal.pone.0177773 Text en © 2017 Gallagher et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Gallagher, Katherine E. Howard, Natasha Kabakama, Severin Mounier-Jack, Sandra Griffiths, Ulla K. Feletto, Marta Burchett, Helen E. D. LaMontagne, D. Scott Watson-Jones, Deborah Lessons learnt from human papillomavirus (HPV) vaccination in 45 low- and middle-income countries |
title | Lessons learnt from human papillomavirus (HPV) vaccination in 45 low- and middle-income countries |
title_full | Lessons learnt from human papillomavirus (HPV) vaccination in 45 low- and middle-income countries |
title_fullStr | Lessons learnt from human papillomavirus (HPV) vaccination in 45 low- and middle-income countries |
title_full_unstemmed | Lessons learnt from human papillomavirus (HPV) vaccination in 45 low- and middle-income countries |
title_short | Lessons learnt from human papillomavirus (HPV) vaccination in 45 low- and middle-income countries |
title_sort | lessons learnt from human papillomavirus (hpv) vaccination in 45 low- and middle-income countries |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5456063/ https://www.ncbi.nlm.nih.gov/pubmed/28575074 http://dx.doi.org/10.1371/journal.pone.0177773 |
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