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Serum Wisteria Floribunda Agglutinin-Positive Mac-2 Binding Protein Could Not Always Predict Early Cirrhosis in Non-Viral Liver Diseases

Background: Wisteria floribunda agglutinin-positive human Mac-2-binding protein (WFA(+)-M2BP) is a novel non-invasive marker of liver fibrosis. The goal of the study was to investigate whether the novel serum biomarker WFA(+)-M2BP or other non-invasive markers are useful for the prediction of liver...

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Autores principales: Haga, Yuki, Kanda, Tatsuo, Sasaki, Reina, Nakamura, Masato, Takahashi, Koji, Wu, Shuang, Yasui, Shin, Arai, Makoto, Nakamoto, Shingo, Yokosuka, Osamu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5456321/
https://www.ncbi.nlm.nih.gov/pubmed/28933417
http://dx.doi.org/10.3390/diseases4040038
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author Haga, Yuki
Kanda, Tatsuo
Sasaki, Reina
Nakamura, Masato
Takahashi, Koji
Wu, Shuang
Yasui, Shin
Arai, Makoto
Nakamoto, Shingo
Yokosuka, Osamu
author_facet Haga, Yuki
Kanda, Tatsuo
Sasaki, Reina
Nakamura, Masato
Takahashi, Koji
Wu, Shuang
Yasui, Shin
Arai, Makoto
Nakamoto, Shingo
Yokosuka, Osamu
author_sort Haga, Yuki
collection PubMed
description Background: Wisteria floribunda agglutinin-positive human Mac-2-binding protein (WFA(+)-M2BP) is a novel non-invasive marker of liver fibrosis. The goal of the study was to investigate whether the novel serum biomarker WFA(+)-M2BP or other non-invasive markers are useful for the prediction of liver fibrosis in patients with nonalcoholic steatohepatitis (NASH), autoimmune hepatitis (AIH), and primary biliary cholangitis (PBC). Methods: We examined a significant correlation between serum WFA(+)-M2BP levels and histological staging of fibrosis in several chronic liver diseases, such as NASH, AIH, and PBC. Results: WFA(+)-M2BP could not predict hepatic fibrosis in these patients. We also showed that the level of platelet counts is a useful predictor of hepatic fibrosis progression in patients with NASH, AIH, and PBC. There was a significant correlation between staging of fibrosis and grading of activity in the liver in all groups except for AIH patients. Conclusion: Platelet counts can predict hepatic fibrosis in patients with NASH, AIH, or PBC. Clinicians should pay attention to the grading of liver activity in the use of WFA(+)-M2BP.
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spelling pubmed-54563212017-09-12 Serum Wisteria Floribunda Agglutinin-Positive Mac-2 Binding Protein Could Not Always Predict Early Cirrhosis in Non-Viral Liver Diseases Haga, Yuki Kanda, Tatsuo Sasaki, Reina Nakamura, Masato Takahashi, Koji Wu, Shuang Yasui, Shin Arai, Makoto Nakamoto, Shingo Yokosuka, Osamu Diseases Article Background: Wisteria floribunda agglutinin-positive human Mac-2-binding protein (WFA(+)-M2BP) is a novel non-invasive marker of liver fibrosis. The goal of the study was to investigate whether the novel serum biomarker WFA(+)-M2BP or other non-invasive markers are useful for the prediction of liver fibrosis in patients with nonalcoholic steatohepatitis (NASH), autoimmune hepatitis (AIH), and primary biliary cholangitis (PBC). Methods: We examined a significant correlation between serum WFA(+)-M2BP levels and histological staging of fibrosis in several chronic liver diseases, such as NASH, AIH, and PBC. Results: WFA(+)-M2BP could not predict hepatic fibrosis in these patients. We also showed that the level of platelet counts is a useful predictor of hepatic fibrosis progression in patients with NASH, AIH, and PBC. There was a significant correlation between staging of fibrosis and grading of activity in the liver in all groups except for AIH patients. Conclusion: Platelet counts can predict hepatic fibrosis in patients with NASH, AIH, or PBC. Clinicians should pay attention to the grading of liver activity in the use of WFA(+)-M2BP. MDPI 2016-12-14 /pmc/articles/PMC5456321/ /pubmed/28933417 http://dx.doi.org/10.3390/diseases4040038 Text en © 2016 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Haga, Yuki
Kanda, Tatsuo
Sasaki, Reina
Nakamura, Masato
Takahashi, Koji
Wu, Shuang
Yasui, Shin
Arai, Makoto
Nakamoto, Shingo
Yokosuka, Osamu
Serum Wisteria Floribunda Agglutinin-Positive Mac-2 Binding Protein Could Not Always Predict Early Cirrhosis in Non-Viral Liver Diseases
title Serum Wisteria Floribunda Agglutinin-Positive Mac-2 Binding Protein Could Not Always Predict Early Cirrhosis in Non-Viral Liver Diseases
title_full Serum Wisteria Floribunda Agglutinin-Positive Mac-2 Binding Protein Could Not Always Predict Early Cirrhosis in Non-Viral Liver Diseases
title_fullStr Serum Wisteria Floribunda Agglutinin-Positive Mac-2 Binding Protein Could Not Always Predict Early Cirrhosis in Non-Viral Liver Diseases
title_full_unstemmed Serum Wisteria Floribunda Agglutinin-Positive Mac-2 Binding Protein Could Not Always Predict Early Cirrhosis in Non-Viral Liver Diseases
title_short Serum Wisteria Floribunda Agglutinin-Positive Mac-2 Binding Protein Could Not Always Predict Early Cirrhosis in Non-Viral Liver Diseases
title_sort serum wisteria floribunda agglutinin-positive mac-2 binding protein could not always predict early cirrhosis in non-viral liver diseases
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5456321/
https://www.ncbi.nlm.nih.gov/pubmed/28933417
http://dx.doi.org/10.3390/diseases4040038
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