Long-term consequences of developmental vascular defects on retinal vessel homeostasis and function in a mouse model of Norrie disease

Loss of Norrin signalling due to mutations in the Norrie disease pseudoglioma gene causes severe vascular defects in the retina, leading to visual impairment and ultimately blindness. While the emphasis of experimental work so far was on the developmental period, we focus here on disease mechanisms...

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Detalles Bibliográficos
Autores principales: Beck, Susanne C., Feng, Yuxi, Sothilingam, Vithiyanjali, Garcia Garrido, Marina, Tanimoto, Naoyuki, Acar, Niyazi, Shan, Shenliang, Seebauer, Britta, Berger, Wolfgang, Hammes, Hans-Peter, Seeliger, Mathias W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5456345/
https://www.ncbi.nlm.nih.gov/pubmed/28575130
http://dx.doi.org/10.1371/journal.pone.0178753

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