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Cognitive and affective trait and state factors influencing the long-term symptom course in remitted depressed patients

BACKGROUND: Major depressive disorder (MDD) is characterized by a high risk for relapses and chronic developments. Clinical characteristics such as residual symptoms have been shown to negatively affect the long-term course of MDD. However, it is unclear so far how trait repetitive negative thinking...

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Autores principales: Timm, Christina, Ubl, Bettina, Zamoscik, Vera, Ebner-Priemer, Ulrich, Reinhard, Iris, Huffziger, Silke, Kirsch, Peter, Kuehner, Christine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5456349/
https://www.ncbi.nlm.nih.gov/pubmed/28575049
http://dx.doi.org/10.1371/journal.pone.0178759
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author Timm, Christina
Ubl, Bettina
Zamoscik, Vera
Ebner-Priemer, Ulrich
Reinhard, Iris
Huffziger, Silke
Kirsch, Peter
Kuehner, Christine
author_facet Timm, Christina
Ubl, Bettina
Zamoscik, Vera
Ebner-Priemer, Ulrich
Reinhard, Iris
Huffziger, Silke
Kirsch, Peter
Kuehner, Christine
author_sort Timm, Christina
collection PubMed
description BACKGROUND: Major depressive disorder (MDD) is characterized by a high risk for relapses and chronic developments. Clinical characteristics such as residual symptoms have been shown to negatively affect the long-term course of MDD. However, it is unclear so far how trait repetitive negative thinking (RNT) as well as cognitive and affective momentary states, the latter experienced during daily-life, affect the long-term course of MDD. METHOD: We followed up 57 remitted depressed (rMDD) individuals six (T2) and 36 (T3) months after baseline. Clinical outcomes were time to relapse, time spent with significant symptoms as a marker of chronicity, and levels of depressive symptoms at T2 and T3. Predictors assessed at baseline included residual symptoms and trait RNT. Furthermore, momentary daily life affect and momentary rumination, and their variation over the day were assessed at baseline using ambulatory assessment (AA). RESULTS: In multiple models, residual symptoms and instability of daily-life affect at baseline independently predicted a faster time to relapse, while chronicity was significantly predicted by trait RNT. Multilevel models revealed that depressive symptom levels during follow-up were predicted by baseline residual symptom levels and by instability of daily-life rumination. Both instability features were linked to a higher number of anamnestic MDD episodes. CONCLUSIONS: Our findings indicate that trait RNT, but also affective and cognitive processes during daily life impact the longer-term course of MDD. Future longitudinal research on the role of respective AA-phenotypes as potential transdiagnostic course-modifiers is warranted.
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spelling pubmed-54563492017-06-12 Cognitive and affective trait and state factors influencing the long-term symptom course in remitted depressed patients Timm, Christina Ubl, Bettina Zamoscik, Vera Ebner-Priemer, Ulrich Reinhard, Iris Huffziger, Silke Kirsch, Peter Kuehner, Christine PLoS One Research Article BACKGROUND: Major depressive disorder (MDD) is characterized by a high risk for relapses and chronic developments. Clinical characteristics such as residual symptoms have been shown to negatively affect the long-term course of MDD. However, it is unclear so far how trait repetitive negative thinking (RNT) as well as cognitive and affective momentary states, the latter experienced during daily-life, affect the long-term course of MDD. METHOD: We followed up 57 remitted depressed (rMDD) individuals six (T2) and 36 (T3) months after baseline. Clinical outcomes were time to relapse, time spent with significant symptoms as a marker of chronicity, and levels of depressive symptoms at T2 and T3. Predictors assessed at baseline included residual symptoms and trait RNT. Furthermore, momentary daily life affect and momentary rumination, and their variation over the day were assessed at baseline using ambulatory assessment (AA). RESULTS: In multiple models, residual symptoms and instability of daily-life affect at baseline independently predicted a faster time to relapse, while chronicity was significantly predicted by trait RNT. Multilevel models revealed that depressive symptom levels during follow-up were predicted by baseline residual symptom levels and by instability of daily-life rumination. Both instability features were linked to a higher number of anamnestic MDD episodes. CONCLUSIONS: Our findings indicate that trait RNT, but also affective and cognitive processes during daily life impact the longer-term course of MDD. Future longitudinal research on the role of respective AA-phenotypes as potential transdiagnostic course-modifiers is warranted. Public Library of Science 2017-06-02 /pmc/articles/PMC5456349/ /pubmed/28575049 http://dx.doi.org/10.1371/journal.pone.0178759 Text en © 2017 Timm et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Timm, Christina
Ubl, Bettina
Zamoscik, Vera
Ebner-Priemer, Ulrich
Reinhard, Iris
Huffziger, Silke
Kirsch, Peter
Kuehner, Christine
Cognitive and affective trait and state factors influencing the long-term symptom course in remitted depressed patients
title Cognitive and affective trait and state factors influencing the long-term symptom course in remitted depressed patients
title_full Cognitive and affective trait and state factors influencing the long-term symptom course in remitted depressed patients
title_fullStr Cognitive and affective trait and state factors influencing the long-term symptom course in remitted depressed patients
title_full_unstemmed Cognitive and affective trait and state factors influencing the long-term symptom course in remitted depressed patients
title_short Cognitive and affective trait and state factors influencing the long-term symptom course in remitted depressed patients
title_sort cognitive and affective trait and state factors influencing the long-term symptom course in remitted depressed patients
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5456349/
https://www.ncbi.nlm.nih.gov/pubmed/28575049
http://dx.doi.org/10.1371/journal.pone.0178759
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