Activating NOTCH1 Mutations Define a Distinct Subgroup of Patients With Adenoid Cystic Carcinoma Who Have Poor Prognosis, Propensity to Bone and Liver Metastasis, and Potential Responsiveness to Notch1 Inhibitors

PURPOSE: Adenoid cystic carcinomas (ACCs) represent a heterogeneous group of chemotherapy refractory tumors, with a subset demonstrating an aggressive phenotype. We investigated the molecular underpinnings of this phenotype and assessed the Notch1 pathway as a potential therapeutic target. METHODS:...

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Detalles Bibliográficos
Autores principales: Ferrarotto, Renata, Mitani, Yoshitsugu, Diao, Lixia, Guijarro, Irene, Wang, Jing, Zweidler-McKay, Patrick, Bell, Diana, William, William N., Glisson, Bonnie S., Wick, Michael J., Kapoun, Ann M., Patnaik, Amita, Eckhardt, Gail, Munster, Pamela, Faoro, Leonardo, Dupont, Jakob, Lee, J. Jack, Futreal, Andrew, El-Naggar, Adel K., Heymach, John V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Clinical Oncology 2017
Materias:
Biology of Neoplasia
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5456373/
https://www.ncbi.nlm.nih.gov/pubmed/27870570
http://dx.doi.org/10.1200/JCO.2016.67.5264

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