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FAS-associated factor-1 positively regulates type I interferon response to RNA virus infection by targeting NLRX1

FAS-associated factor-1 (FAF1) is a component of the death-inducing signaling complex involved in Fas-mediated apoptosis. It regulates NF-κB activity, ubiquitination, and proteasomal degradation. Here, we found that FAF1 positively regulates the type I interferon pathway. FAF1(gt/gt) mice, which def...

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Autores principales: Kim, Jae-Hoon, Park, Min-Eun, Nikapitiya, Chamilani, Kim, Tae-Hwan, Uddin, Md Bashir, Lee, Hyun-Cheol, Kim, Eunhee, Ma, Jin Yeul, Jung, Jae U., Kim, Chul-Joong, Lee, Jong-Soo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5456407/
https://www.ncbi.nlm.nih.gov/pubmed/28542569
http://dx.doi.org/10.1371/journal.ppat.1006398
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author Kim, Jae-Hoon
Park, Min-Eun
Nikapitiya, Chamilani
Kim, Tae-Hwan
Uddin, Md Bashir
Lee, Hyun-Cheol
Kim, Eunhee
Ma, Jin Yeul
Jung, Jae U.
Kim, Chul-Joong
Lee, Jong-Soo
author_facet Kim, Jae-Hoon
Park, Min-Eun
Nikapitiya, Chamilani
Kim, Tae-Hwan
Uddin, Md Bashir
Lee, Hyun-Cheol
Kim, Eunhee
Ma, Jin Yeul
Jung, Jae U.
Kim, Chul-Joong
Lee, Jong-Soo
author_sort Kim, Jae-Hoon
collection PubMed
description FAS-associated factor-1 (FAF1) is a component of the death-inducing signaling complex involved in Fas-mediated apoptosis. It regulates NF-κB activity, ubiquitination, and proteasomal degradation. Here, we found that FAF1 positively regulates the type I interferon pathway. FAF1(gt/gt) mice, which deficient in FAF1, and FAF1 knockdown immune cells were highly susceptible to RNA virus infection and showed low levels of inflammatory cytokines and type I interferon (IFN) production. FAF1 was bound competitively to NLRX1 and positively regulated type I IFN signaling by interfering with the interaction between NLRX1 and MAVS, thereby freeing MAVS to bind RIG-I, which switched on the MAVS-RIG-I-mediated antiviral signaling cascade. These results highlight a critical role of FAF1 in antiviral responses against RNA virus infection.
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spelling pubmed-54564072017-06-06 FAS-associated factor-1 positively regulates type I interferon response to RNA virus infection by targeting NLRX1 Kim, Jae-Hoon Park, Min-Eun Nikapitiya, Chamilani Kim, Tae-Hwan Uddin, Md Bashir Lee, Hyun-Cheol Kim, Eunhee Ma, Jin Yeul Jung, Jae U. Kim, Chul-Joong Lee, Jong-Soo PLoS Pathog Research Article FAS-associated factor-1 (FAF1) is a component of the death-inducing signaling complex involved in Fas-mediated apoptosis. It regulates NF-κB activity, ubiquitination, and proteasomal degradation. Here, we found that FAF1 positively regulates the type I interferon pathway. FAF1(gt/gt) mice, which deficient in FAF1, and FAF1 knockdown immune cells were highly susceptible to RNA virus infection and showed low levels of inflammatory cytokines and type I interferon (IFN) production. FAF1 was bound competitively to NLRX1 and positively regulated type I IFN signaling by interfering with the interaction between NLRX1 and MAVS, thereby freeing MAVS to bind RIG-I, which switched on the MAVS-RIG-I-mediated antiviral signaling cascade. These results highlight a critical role of FAF1 in antiviral responses against RNA virus infection. Public Library of Science 2017-05-22 /pmc/articles/PMC5456407/ /pubmed/28542569 http://dx.doi.org/10.1371/journal.ppat.1006398 Text en © 2017 Kim et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Kim, Jae-Hoon
Park, Min-Eun
Nikapitiya, Chamilani
Kim, Tae-Hwan
Uddin, Md Bashir
Lee, Hyun-Cheol
Kim, Eunhee
Ma, Jin Yeul
Jung, Jae U.
Kim, Chul-Joong
Lee, Jong-Soo
FAS-associated factor-1 positively regulates type I interferon response to RNA virus infection by targeting NLRX1
title FAS-associated factor-1 positively regulates type I interferon response to RNA virus infection by targeting NLRX1
title_full FAS-associated factor-1 positively regulates type I interferon response to RNA virus infection by targeting NLRX1
title_fullStr FAS-associated factor-1 positively regulates type I interferon response to RNA virus infection by targeting NLRX1
title_full_unstemmed FAS-associated factor-1 positively regulates type I interferon response to RNA virus infection by targeting NLRX1
title_short FAS-associated factor-1 positively regulates type I interferon response to RNA virus infection by targeting NLRX1
title_sort fas-associated factor-1 positively regulates type i interferon response to rna virus infection by targeting nlrx1
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5456407/
https://www.ncbi.nlm.nih.gov/pubmed/28542569
http://dx.doi.org/10.1371/journal.ppat.1006398
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