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FAS-associated factor-1 positively regulates type I interferon response to RNA virus infection by targeting NLRX1

FAS-associated factor-1 (FAF1) is a component of the death-inducing signaling complex involved in Fas-mediated apoptosis. It regulates NF-κB activity, ubiquitination, and proteasomal degradation. Here, we found that FAF1 positively regulates the type I interferon pathway. FAF1(gt/gt) mice, which def...

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Detalles Bibliográficos
Autores principales:	Kim, Jae-Hoon, Park, Min-Eun, Nikapitiya, Chamilani, Kim, Tae-Hwan, Uddin, Md Bashir, Lee, Hyun-Cheol, Kim, Eunhee, Ma, Jin Yeul, Jung, Jae U., Kim, Chul-Joong, Lee, Jong-Soo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5456407/ https://www.ncbi.nlm.nih.gov/pubmed/28542569 http://dx.doi.org/10.1371/journal.ppat.1006398

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