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Thickness Influence on In Vitro Biocompatibility of Titanium Nitride Thin Films Synthesized by Pulsed Laser Deposition
We report a study on the biocompatibility vs. thickness in the case of titanium nitride (TiN) films synthesized on 410 medical grade stainless steel substrates by pulsed laser deposition. The films were grown in a nitrogen atmosphere, and their in vitro cytotoxicity was assessed according to ISO 109...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5456537/ https://www.ncbi.nlm.nih.gov/pubmed/28787846 http://dx.doi.org/10.3390/ma9010038 |
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author | Duta, Liviu Stan, George E. Popa, Adrian C. Husanu, Marius A. Moga, Sorin Socol, Marcela Zgura, Irina Miculescu, Florin Urzica, Iuliana Popescu, Andrei C. Mihailescu, Ion N. |
author_facet | Duta, Liviu Stan, George E. Popa, Adrian C. Husanu, Marius A. Moga, Sorin Socol, Marcela Zgura, Irina Miculescu, Florin Urzica, Iuliana Popescu, Andrei C. Mihailescu, Ion N. |
author_sort | Duta, Liviu |
collection | PubMed |
description | We report a study on the biocompatibility vs. thickness in the case of titanium nitride (TiN) films synthesized on 410 medical grade stainless steel substrates by pulsed laser deposition. The films were grown in a nitrogen atmosphere, and their in vitro cytotoxicity was assessed according to ISO 10993-5 [1]. Extensive physical-chemical analyses have been carried out on the deposited structures with various thicknesses in order to explain the differences in biological behavior: profilometry, scanning electron microscopy, atomic force microscopy, X-ray photoelectron spectroscopy (XPS), X-ray diffraction and surface energy measurements. XPS revealed the presence of titanium oxynitride beside TiN in amounts that vary with the film thickness. The cytocompatibility of films seems to be influenced by their TiN surface content. The thinner films seem to be more suitable for medical applications, due to the combined high values of bonding strength and superior cytocompatibility. |
format | Online Article Text |
id | pubmed-5456537 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-54565372017-07-28 Thickness Influence on In Vitro Biocompatibility of Titanium Nitride Thin Films Synthesized by Pulsed Laser Deposition Duta, Liviu Stan, George E. Popa, Adrian C. Husanu, Marius A. Moga, Sorin Socol, Marcela Zgura, Irina Miculescu, Florin Urzica, Iuliana Popescu, Andrei C. Mihailescu, Ion N. Materials (Basel) Article We report a study on the biocompatibility vs. thickness in the case of titanium nitride (TiN) films synthesized on 410 medical grade stainless steel substrates by pulsed laser deposition. The films were grown in a nitrogen atmosphere, and their in vitro cytotoxicity was assessed according to ISO 10993-5 [1]. Extensive physical-chemical analyses have been carried out on the deposited structures with various thicknesses in order to explain the differences in biological behavior: profilometry, scanning electron microscopy, atomic force microscopy, X-ray photoelectron spectroscopy (XPS), X-ray diffraction and surface energy measurements. XPS revealed the presence of titanium oxynitride beside TiN in amounts that vary with the film thickness. The cytocompatibility of films seems to be influenced by their TiN surface content. The thinner films seem to be more suitable for medical applications, due to the combined high values of bonding strength and superior cytocompatibility. MDPI 2016-01-13 /pmc/articles/PMC5456537/ /pubmed/28787846 http://dx.doi.org/10.3390/ma9010038 Text en © 2016 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Duta, Liviu Stan, George E. Popa, Adrian C. Husanu, Marius A. Moga, Sorin Socol, Marcela Zgura, Irina Miculescu, Florin Urzica, Iuliana Popescu, Andrei C. Mihailescu, Ion N. Thickness Influence on In Vitro Biocompatibility of Titanium Nitride Thin Films Synthesized by Pulsed Laser Deposition |
title | Thickness Influence on In Vitro Biocompatibility of Titanium Nitride Thin Films Synthesized by Pulsed Laser Deposition |
title_full | Thickness Influence on In Vitro Biocompatibility of Titanium Nitride Thin Films Synthesized by Pulsed Laser Deposition |
title_fullStr | Thickness Influence on In Vitro Biocompatibility of Titanium Nitride Thin Films Synthesized by Pulsed Laser Deposition |
title_full_unstemmed | Thickness Influence on In Vitro Biocompatibility of Titanium Nitride Thin Films Synthesized by Pulsed Laser Deposition |
title_short | Thickness Influence on In Vitro Biocompatibility of Titanium Nitride Thin Films Synthesized by Pulsed Laser Deposition |
title_sort | thickness influence on in vitro biocompatibility of titanium nitride thin films synthesized by pulsed laser deposition |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5456537/ https://www.ncbi.nlm.nih.gov/pubmed/28787846 http://dx.doi.org/10.3390/ma9010038 |
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