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µXRF Elemental Mapping of Bioresorbable Magnesium-Based Implants in Bone

This study investigated the distribution of the elemental constituents of Mg-based implants at various stages of the degradation process in surrounding bone tissue, with a focus on magnesium (Mg), as the main component of the alloy, and yttrium (Y), due to its potential adverse health effects. The m...

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Detalles Bibliográficos
Autores principales: Turyanskaya, Anna, Rauwolf, Mirjam, Grünewald, Tilman A., Meischel, Martin, Stanzl-Tschegg, Stefanie, Löffler, Jörg F., Wobrauschek, Peter, Weinberg, Annelie M., Lichtenegger, Helga C., Streli, Christina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5456597/
https://www.ncbi.nlm.nih.gov/pubmed/28773933
http://dx.doi.org/10.3390/ma9100811
Descripción
Sumario:This study investigated the distribution of the elemental constituents of Mg-based implants at various stages of the degradation process in surrounding bone tissue, with a focus on magnesium (Mg), as the main component of the alloy, and yttrium (Y), due to its potential adverse health effects. The measurements were performed on the implant-bearing thin sections of rat bone in a time series of implant degradation between one and 18 months. Micro X-ray fluorescence analysis (μXRF) with a special spectrometer meeting the requirements for the measurements of low-Z elements was used. It was found that the migration and accumulation behaviour of implant degradation products is element-specific. A sharp decrease in Mg was observed in the immediate vicinity of the interface and no specific accumulation or aggregation of Mg in the adjacent bone tissue was detected. By contrast, Y was found to migrate further into the bone over time and to remain in the tissue even after the complete degradation of the implant. Although the nature of Y accumulations must still be clarified, its potential health impact should be considered.