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µXRF Elemental Mapping of Bioresorbable Magnesium-Based Implants in Bone
This study investigated the distribution of the elemental constituents of Mg-based implants at various stages of the degradation process in surrounding bone tissue, with a focus on magnesium (Mg), as the main component of the alloy, and yttrium (Y), due to its potential adverse health effects. The m...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5456597/ https://www.ncbi.nlm.nih.gov/pubmed/28773933 http://dx.doi.org/10.3390/ma9100811 |
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author | Turyanskaya, Anna Rauwolf, Mirjam Grünewald, Tilman A. Meischel, Martin Stanzl-Tschegg, Stefanie Löffler, Jörg F. Wobrauschek, Peter Weinberg, Annelie M. Lichtenegger, Helga C. Streli, Christina |
author_facet | Turyanskaya, Anna Rauwolf, Mirjam Grünewald, Tilman A. Meischel, Martin Stanzl-Tschegg, Stefanie Löffler, Jörg F. Wobrauschek, Peter Weinberg, Annelie M. Lichtenegger, Helga C. Streli, Christina |
author_sort | Turyanskaya, Anna |
collection | PubMed |
description | This study investigated the distribution of the elemental constituents of Mg-based implants at various stages of the degradation process in surrounding bone tissue, with a focus on magnesium (Mg), as the main component of the alloy, and yttrium (Y), due to its potential adverse health effects. The measurements were performed on the implant-bearing thin sections of rat bone in a time series of implant degradation between one and 18 months. Micro X-ray fluorescence analysis (μXRF) with a special spectrometer meeting the requirements for the measurements of low-Z elements was used. It was found that the migration and accumulation behaviour of implant degradation products is element-specific. A sharp decrease in Mg was observed in the immediate vicinity of the interface and no specific accumulation or aggregation of Mg in the adjacent bone tissue was detected. By contrast, Y was found to migrate further into the bone over time and to remain in the tissue even after the complete degradation of the implant. Although the nature of Y accumulations must still be clarified, its potential health impact should be considered. |
format | Online Article Text |
id | pubmed-5456597 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-54565972017-07-28 µXRF Elemental Mapping of Bioresorbable Magnesium-Based Implants in Bone Turyanskaya, Anna Rauwolf, Mirjam Grünewald, Tilman A. Meischel, Martin Stanzl-Tschegg, Stefanie Löffler, Jörg F. Wobrauschek, Peter Weinberg, Annelie M. Lichtenegger, Helga C. Streli, Christina Materials (Basel) Article This study investigated the distribution of the elemental constituents of Mg-based implants at various stages of the degradation process in surrounding bone tissue, with a focus on magnesium (Mg), as the main component of the alloy, and yttrium (Y), due to its potential adverse health effects. The measurements were performed on the implant-bearing thin sections of rat bone in a time series of implant degradation between one and 18 months. Micro X-ray fluorescence analysis (μXRF) with a special spectrometer meeting the requirements for the measurements of low-Z elements was used. It was found that the migration and accumulation behaviour of implant degradation products is element-specific. A sharp decrease in Mg was observed in the immediate vicinity of the interface and no specific accumulation or aggregation of Mg in the adjacent bone tissue was detected. By contrast, Y was found to migrate further into the bone over time and to remain in the tissue even after the complete degradation of the implant. Although the nature of Y accumulations must still be clarified, its potential health impact should be considered. MDPI 2016-09-30 /pmc/articles/PMC5456597/ /pubmed/28773933 http://dx.doi.org/10.3390/ma9100811 Text en © 2016 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Turyanskaya, Anna Rauwolf, Mirjam Grünewald, Tilman A. Meischel, Martin Stanzl-Tschegg, Stefanie Löffler, Jörg F. Wobrauschek, Peter Weinberg, Annelie M. Lichtenegger, Helga C. Streli, Christina µXRF Elemental Mapping of Bioresorbable Magnesium-Based Implants in Bone |
title | µXRF Elemental Mapping of Bioresorbable Magnesium-Based Implants in Bone |
title_full | µXRF Elemental Mapping of Bioresorbable Magnesium-Based Implants in Bone |
title_fullStr | µXRF Elemental Mapping of Bioresorbable Magnesium-Based Implants in Bone |
title_full_unstemmed | µXRF Elemental Mapping of Bioresorbable Magnesium-Based Implants in Bone |
title_short | µXRF Elemental Mapping of Bioresorbable Magnesium-Based Implants in Bone |
title_sort | µxrf elemental mapping of bioresorbable magnesium-based implants in bone |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5456597/ https://www.ncbi.nlm.nih.gov/pubmed/28773933 http://dx.doi.org/10.3390/ma9100811 |
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