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µXRF Elemental Mapping of Bioresorbable Magnesium-Based Implants in Bone

This study investigated the distribution of the elemental constituents of Mg-based implants at various stages of the degradation process in surrounding bone tissue, with a focus on magnesium (Mg), as the main component of the alloy, and yttrium (Y), due to its potential adverse health effects. The m...

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Autores principales: Turyanskaya, Anna, Rauwolf, Mirjam, Grünewald, Tilman A., Meischel, Martin, Stanzl-Tschegg, Stefanie, Löffler, Jörg F., Wobrauschek, Peter, Weinberg, Annelie M., Lichtenegger, Helga C., Streli, Christina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5456597/
https://www.ncbi.nlm.nih.gov/pubmed/28773933
http://dx.doi.org/10.3390/ma9100811
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author Turyanskaya, Anna
Rauwolf, Mirjam
Grünewald, Tilman A.
Meischel, Martin
Stanzl-Tschegg, Stefanie
Löffler, Jörg F.
Wobrauschek, Peter
Weinberg, Annelie M.
Lichtenegger, Helga C.
Streli, Christina
author_facet Turyanskaya, Anna
Rauwolf, Mirjam
Grünewald, Tilman A.
Meischel, Martin
Stanzl-Tschegg, Stefanie
Löffler, Jörg F.
Wobrauschek, Peter
Weinberg, Annelie M.
Lichtenegger, Helga C.
Streli, Christina
author_sort Turyanskaya, Anna
collection PubMed
description This study investigated the distribution of the elemental constituents of Mg-based implants at various stages of the degradation process in surrounding bone tissue, with a focus on magnesium (Mg), as the main component of the alloy, and yttrium (Y), due to its potential adverse health effects. The measurements were performed on the implant-bearing thin sections of rat bone in a time series of implant degradation between one and 18 months. Micro X-ray fluorescence analysis (μXRF) with a special spectrometer meeting the requirements for the measurements of low-Z elements was used. It was found that the migration and accumulation behaviour of implant degradation products is element-specific. A sharp decrease in Mg was observed in the immediate vicinity of the interface and no specific accumulation or aggregation of Mg in the adjacent bone tissue was detected. By contrast, Y was found to migrate further into the bone over time and to remain in the tissue even after the complete degradation of the implant. Although the nature of Y accumulations must still be clarified, its potential health impact should be considered.
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spelling pubmed-54565972017-07-28 µXRF Elemental Mapping of Bioresorbable Magnesium-Based Implants in Bone Turyanskaya, Anna Rauwolf, Mirjam Grünewald, Tilman A. Meischel, Martin Stanzl-Tschegg, Stefanie Löffler, Jörg F. Wobrauschek, Peter Weinberg, Annelie M. Lichtenegger, Helga C. Streli, Christina Materials (Basel) Article This study investigated the distribution of the elemental constituents of Mg-based implants at various stages of the degradation process in surrounding bone tissue, with a focus on magnesium (Mg), as the main component of the alloy, and yttrium (Y), due to its potential adverse health effects. The measurements were performed on the implant-bearing thin sections of rat bone in a time series of implant degradation between one and 18 months. Micro X-ray fluorescence analysis (μXRF) with a special spectrometer meeting the requirements for the measurements of low-Z elements was used. It was found that the migration and accumulation behaviour of implant degradation products is element-specific. A sharp decrease in Mg was observed in the immediate vicinity of the interface and no specific accumulation or aggregation of Mg in the adjacent bone tissue was detected. By contrast, Y was found to migrate further into the bone over time and to remain in the tissue even after the complete degradation of the implant. Although the nature of Y accumulations must still be clarified, its potential health impact should be considered. MDPI 2016-09-30 /pmc/articles/PMC5456597/ /pubmed/28773933 http://dx.doi.org/10.3390/ma9100811 Text en © 2016 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Turyanskaya, Anna
Rauwolf, Mirjam
Grünewald, Tilman A.
Meischel, Martin
Stanzl-Tschegg, Stefanie
Löffler, Jörg F.
Wobrauschek, Peter
Weinberg, Annelie M.
Lichtenegger, Helga C.
Streli, Christina
µXRF Elemental Mapping of Bioresorbable Magnesium-Based Implants in Bone
title µXRF Elemental Mapping of Bioresorbable Magnesium-Based Implants in Bone
title_full µXRF Elemental Mapping of Bioresorbable Magnesium-Based Implants in Bone
title_fullStr µXRF Elemental Mapping of Bioresorbable Magnesium-Based Implants in Bone
title_full_unstemmed µXRF Elemental Mapping of Bioresorbable Magnesium-Based Implants in Bone
title_short µXRF Elemental Mapping of Bioresorbable Magnesium-Based Implants in Bone
title_sort µxrf elemental mapping of bioresorbable magnesium-based implants in bone
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5456597/
https://www.ncbi.nlm.nih.gov/pubmed/28773933
http://dx.doi.org/10.3390/ma9100811
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