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Synthesis and Structural Characterization of Silver Nanoparticles Stabilized with 3-Mercapto-1-Propansulfonate and 1-Thioglucose Mixed Thiols for Antibacterial Applications
The synthesis, characterization and assessment of the antibacterial properties of hydrophilic silver nanoparticles (AgNPs) were investigated with the aim to probe their suitability for innovative applications in the field of nanobiotechnology. First, silver nanoparticles were synthetized and functio...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5456982/ https://www.ncbi.nlm.nih.gov/pubmed/28774148 http://dx.doi.org/10.3390/ma9121028 |
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author | Porcaro, Francesco Carlini, Laura Ugolini, Andrea Visaggio, Daniela Visca, Paolo Fratoddi, Ilaria Venditti, Iole Meneghini, Carlo Simonelli, Laura Marini, Carlo Olszewski, Wojciech Ramanan, Nitya Luisetto, Igor Battocchio, Chiara |
author_facet | Porcaro, Francesco Carlini, Laura Ugolini, Andrea Visaggio, Daniela Visca, Paolo Fratoddi, Ilaria Venditti, Iole Meneghini, Carlo Simonelli, Laura Marini, Carlo Olszewski, Wojciech Ramanan, Nitya Luisetto, Igor Battocchio, Chiara |
author_sort | Porcaro, Francesco |
collection | PubMed |
description | The synthesis, characterization and assessment of the antibacterial properties of hydrophilic silver nanoparticles (AgNPs) were investigated with the aim to probe their suitability for innovative applications in the field of nanobiotechnology. First, silver nanoparticles were synthetized and functionalized with two capping agents, namely 3-mercapto-1-propansulfonate (3MPS) and 1-β-thio-d-glucose (TG). The investigation of the structural and electronic properties of the nano-systems was carried out by means of X-ray Photoelectron Spectroscopy (XPS) and X-ray Absorption Spectroscopy (XAS). XPS data provided information about the system stability and the interactions between the metallic surface and the organic ligands. In addition, XPS data allowed us to achieve a deep understanding of the influence of the thiols stoichiometric ratio on the electronic properties and stability of AgNPs. In order to shed light on the structural and electronic local properties at Ag atoms sites, XAS at Ag K-Edge was successfully applied; furthermore, the combination of Dynamic Light Scattering (DLS) and XAS results allowed determining AgNPs sizes, ranging between 3 and 13 nm. Finally, preliminary studies on the antibacterial properties of AgNPs showed promising results on four of six multidrug-resistant bacteria belonging to the ESKAPE group (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter sp.). |
format | Online Article Text |
id | pubmed-5456982 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-54569822017-07-28 Synthesis and Structural Characterization of Silver Nanoparticles Stabilized with 3-Mercapto-1-Propansulfonate and 1-Thioglucose Mixed Thiols for Antibacterial Applications Porcaro, Francesco Carlini, Laura Ugolini, Andrea Visaggio, Daniela Visca, Paolo Fratoddi, Ilaria Venditti, Iole Meneghini, Carlo Simonelli, Laura Marini, Carlo Olszewski, Wojciech Ramanan, Nitya Luisetto, Igor Battocchio, Chiara Materials (Basel) Article The synthesis, characterization and assessment of the antibacterial properties of hydrophilic silver nanoparticles (AgNPs) were investigated with the aim to probe their suitability for innovative applications in the field of nanobiotechnology. First, silver nanoparticles were synthetized and functionalized with two capping agents, namely 3-mercapto-1-propansulfonate (3MPS) and 1-β-thio-d-glucose (TG). The investigation of the structural and electronic properties of the nano-systems was carried out by means of X-ray Photoelectron Spectroscopy (XPS) and X-ray Absorption Spectroscopy (XAS). XPS data provided information about the system stability and the interactions between the metallic surface and the organic ligands. In addition, XPS data allowed us to achieve a deep understanding of the influence of the thiols stoichiometric ratio on the electronic properties and stability of AgNPs. In order to shed light on the structural and electronic local properties at Ag atoms sites, XAS at Ag K-Edge was successfully applied; furthermore, the combination of Dynamic Light Scattering (DLS) and XAS results allowed determining AgNPs sizes, ranging between 3 and 13 nm. Finally, preliminary studies on the antibacterial properties of AgNPs showed promising results on four of six multidrug-resistant bacteria belonging to the ESKAPE group (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter sp.). MDPI 2016-12-20 /pmc/articles/PMC5456982/ /pubmed/28774148 http://dx.doi.org/10.3390/ma9121028 Text en © 2016 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Porcaro, Francesco Carlini, Laura Ugolini, Andrea Visaggio, Daniela Visca, Paolo Fratoddi, Ilaria Venditti, Iole Meneghini, Carlo Simonelli, Laura Marini, Carlo Olszewski, Wojciech Ramanan, Nitya Luisetto, Igor Battocchio, Chiara Synthesis and Structural Characterization of Silver Nanoparticles Stabilized with 3-Mercapto-1-Propansulfonate and 1-Thioglucose Mixed Thiols for Antibacterial Applications |
title | Synthesis and Structural Characterization of Silver Nanoparticles Stabilized with 3-Mercapto-1-Propansulfonate and 1-Thioglucose Mixed Thiols for Antibacterial Applications |
title_full | Synthesis and Structural Characterization of Silver Nanoparticles Stabilized with 3-Mercapto-1-Propansulfonate and 1-Thioglucose Mixed Thiols for Antibacterial Applications |
title_fullStr | Synthesis and Structural Characterization of Silver Nanoparticles Stabilized with 3-Mercapto-1-Propansulfonate and 1-Thioglucose Mixed Thiols for Antibacterial Applications |
title_full_unstemmed | Synthesis and Structural Characterization of Silver Nanoparticles Stabilized with 3-Mercapto-1-Propansulfonate and 1-Thioglucose Mixed Thiols for Antibacterial Applications |
title_short | Synthesis and Structural Characterization of Silver Nanoparticles Stabilized with 3-Mercapto-1-Propansulfonate and 1-Thioglucose Mixed Thiols for Antibacterial Applications |
title_sort | synthesis and structural characterization of silver nanoparticles stabilized with 3-mercapto-1-propansulfonate and 1-thioglucose mixed thiols for antibacterial applications |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5456982/ https://www.ncbi.nlm.nih.gov/pubmed/28774148 http://dx.doi.org/10.3390/ma9121028 |
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