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Highly Absorbent Antibacterial Hemostatic Dressing for Healing Severe Hemorrhagic Wounds
To accelerate healing of severe hemorrhagic wounds, a novel highly absorbent hemostatic dressing composed of a Tencel(®)/absorbent-cotton/polylactic acid nonwoven base and chitosan/nanosilver antibacterial agent was fabricated by using a nonwoven processing technique and a freeze-drying technique. T...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5457081/ https://www.ncbi.nlm.nih.gov/pubmed/28773912 http://dx.doi.org/10.3390/ma9090793 |
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author | Li, Ting-Ting Lou, Ching-Wen Chen, An-Pang Lee, Mong-Chuan Ho, Tsing-Fen Chen, Yueh-Sheng Lin, Jia-Horng |
author_facet | Li, Ting-Ting Lou, Ching-Wen Chen, An-Pang Lee, Mong-Chuan Ho, Tsing-Fen Chen, Yueh-Sheng Lin, Jia-Horng |
author_sort | Li, Ting-Ting |
collection | PubMed |
description | To accelerate healing of severe hemorrhagic wounds, a novel highly absorbent hemostatic dressing composed of a Tencel(®)/absorbent-cotton/polylactic acid nonwoven base and chitosan/nanosilver antibacterial agent was fabricated by using a nonwoven processing technique and a freeze-drying technique. This study is the first to investigate the wicking and water-absorbing properties of a nonwoven base by measuring the vertical wicking height and water absorption ratio. Moreover, blood agglutination and hemostatic second tests were conducted to evaluate the hemostatic performance of the resultant wound dressing. The blending ratio of fibers, areal weight, punching density, and fiber orientation, all significantly influenced the vertical moisture wicking property. However, only the first two parameters markedly affected the water absorption ratio. After the nonwoven base absorbed blood, scanning electron microscope (SEM) observation showed that erythrocytes were trapped between the fibrin/clot network and nonwoven fibers when coagulation pathways were activated. Prothrombin time (PT) and activated partial thromboplastin time (APTT) blood agglutination of the resultant dressing decreased to 14.34 and 50.94 s, respectively. In the femoral artery of the rate bleeding model, hemostatic time was saved by 87.2% compared with that of cotton cloth. Therefore, the resultant antibacterial wound dressing demonstrated greater water and blood absorption, as well as hemostatic performance, than the commercially available cotton cloth, especially for healing severe hemorrhagic wounds. |
format | Online Article Text |
id | pubmed-5457081 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-54570812017-07-28 Highly Absorbent Antibacterial Hemostatic Dressing for Healing Severe Hemorrhagic Wounds Li, Ting-Ting Lou, Ching-Wen Chen, An-Pang Lee, Mong-Chuan Ho, Tsing-Fen Chen, Yueh-Sheng Lin, Jia-Horng Materials (Basel) Article To accelerate healing of severe hemorrhagic wounds, a novel highly absorbent hemostatic dressing composed of a Tencel(®)/absorbent-cotton/polylactic acid nonwoven base and chitosan/nanosilver antibacterial agent was fabricated by using a nonwoven processing technique and a freeze-drying technique. This study is the first to investigate the wicking and water-absorbing properties of a nonwoven base by measuring the vertical wicking height and water absorption ratio. Moreover, blood agglutination and hemostatic second tests were conducted to evaluate the hemostatic performance of the resultant wound dressing. The blending ratio of fibers, areal weight, punching density, and fiber orientation, all significantly influenced the vertical moisture wicking property. However, only the first two parameters markedly affected the water absorption ratio. After the nonwoven base absorbed blood, scanning electron microscope (SEM) observation showed that erythrocytes were trapped between the fibrin/clot network and nonwoven fibers when coagulation pathways were activated. Prothrombin time (PT) and activated partial thromboplastin time (APTT) blood agglutination of the resultant dressing decreased to 14.34 and 50.94 s, respectively. In the femoral artery of the rate bleeding model, hemostatic time was saved by 87.2% compared with that of cotton cloth. Therefore, the resultant antibacterial wound dressing demonstrated greater water and blood absorption, as well as hemostatic performance, than the commercially available cotton cloth, especially for healing severe hemorrhagic wounds. MDPI 2016-09-21 /pmc/articles/PMC5457081/ /pubmed/28773912 http://dx.doi.org/10.3390/ma9090793 Text en © 2016 by the authors; Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Li, Ting-Ting Lou, Ching-Wen Chen, An-Pang Lee, Mong-Chuan Ho, Tsing-Fen Chen, Yueh-Sheng Lin, Jia-Horng Highly Absorbent Antibacterial Hemostatic Dressing for Healing Severe Hemorrhagic Wounds |
title | Highly Absorbent Antibacterial Hemostatic Dressing for Healing Severe Hemorrhagic Wounds |
title_full | Highly Absorbent Antibacterial Hemostatic Dressing for Healing Severe Hemorrhagic Wounds |
title_fullStr | Highly Absorbent Antibacterial Hemostatic Dressing for Healing Severe Hemorrhagic Wounds |
title_full_unstemmed | Highly Absorbent Antibacterial Hemostatic Dressing for Healing Severe Hemorrhagic Wounds |
title_short | Highly Absorbent Antibacterial Hemostatic Dressing for Healing Severe Hemorrhagic Wounds |
title_sort | highly absorbent antibacterial hemostatic dressing for healing severe hemorrhagic wounds |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5457081/ https://www.ncbi.nlm.nih.gov/pubmed/28773912 http://dx.doi.org/10.3390/ma9090793 |
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