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Nonionic Microemulsions as Solubilizers of Hydrophobic Drugs: Solubilization of Paclitaxel
The strategy using nonionic microemulsion as a solubilizer for hydrophobic drugs was studied and is demonstrated in this work. The aqueous phase behaviors of mixed nonionic surfactants with various oils at 37 °C are firstly constructed to give the optimal formulations of nonionic microemulsions with...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5457098/ https://www.ncbi.nlm.nih.gov/pubmed/28773882 http://dx.doi.org/10.3390/ma9090761 |
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author | Lo, Jen-Ting Lee, Tzer-Min Chen, Bing-Hung |
author_facet | Lo, Jen-Ting Lee, Tzer-Min Chen, Bing-Hung |
author_sort | Lo, Jen-Ting |
collection | PubMed |
description | The strategy using nonionic microemulsion as a solubilizer for hydrophobic drugs was studied and is demonstrated in this work. The aqueous phase behaviors of mixed nonionic surfactants with various oils at 37 °C are firstly constructed to give the optimal formulations of nonionic microemulsions with applications in the enhanced solubilization of the model hydrophobic drug, paclitaxel, at 37 °C. Briefly, the suitable oil phase with paclitaxel significantly dissolved is microemulsified with appropriate surfactants. Surfactants utilized include Tween 80, Cremophor EL, and polyethylene glycol (4.3) cocoyl ether, while various kinds of edible oils and fatty esters are used as the oil phase. On average, the apparent solubility of paclitaxel is increased to ca. 70–100 ppm in the prepared microemulsions at 37 °C using tributyrin or ethyl caproate as the oil phases. The sizes of the microemulsions attained are mostly from ca. 60 nm to ca. 200 nm. The cytotoxicity of the microemulsion formulations is assessed with the cellular viability of 3T3 cells. In general, the cell viability is above 55% after 24 h of cultivation in media containing these microemulsion formulations diluted to a concentration of total surfactants equal to 50 ppm and 200 ppm. |
format | Online Article Text |
id | pubmed-5457098 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-54570982017-07-28 Nonionic Microemulsions as Solubilizers of Hydrophobic Drugs: Solubilization of Paclitaxel Lo, Jen-Ting Lee, Tzer-Min Chen, Bing-Hung Materials (Basel) Article The strategy using nonionic microemulsion as a solubilizer for hydrophobic drugs was studied and is demonstrated in this work. The aqueous phase behaviors of mixed nonionic surfactants with various oils at 37 °C are firstly constructed to give the optimal formulations of nonionic microemulsions with applications in the enhanced solubilization of the model hydrophobic drug, paclitaxel, at 37 °C. Briefly, the suitable oil phase with paclitaxel significantly dissolved is microemulsified with appropriate surfactants. Surfactants utilized include Tween 80, Cremophor EL, and polyethylene glycol (4.3) cocoyl ether, while various kinds of edible oils and fatty esters are used as the oil phase. On average, the apparent solubility of paclitaxel is increased to ca. 70–100 ppm in the prepared microemulsions at 37 °C using tributyrin or ethyl caproate as the oil phases. The sizes of the microemulsions attained are mostly from ca. 60 nm to ca. 200 nm. The cytotoxicity of the microemulsion formulations is assessed with the cellular viability of 3T3 cells. In general, the cell viability is above 55% after 24 h of cultivation in media containing these microemulsion formulations diluted to a concentration of total surfactants equal to 50 ppm and 200 ppm. MDPI 2016-09-07 /pmc/articles/PMC5457098/ /pubmed/28773882 http://dx.doi.org/10.3390/ma9090761 Text en © 2016 by the authors; Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Lo, Jen-Ting Lee, Tzer-Min Chen, Bing-Hung Nonionic Microemulsions as Solubilizers of Hydrophobic Drugs: Solubilization of Paclitaxel |
title | Nonionic Microemulsions as Solubilizers of Hydrophobic Drugs: Solubilization of Paclitaxel |
title_full | Nonionic Microemulsions as Solubilizers of Hydrophobic Drugs: Solubilization of Paclitaxel |
title_fullStr | Nonionic Microemulsions as Solubilizers of Hydrophobic Drugs: Solubilization of Paclitaxel |
title_full_unstemmed | Nonionic Microemulsions as Solubilizers of Hydrophobic Drugs: Solubilization of Paclitaxel |
title_short | Nonionic Microemulsions as Solubilizers of Hydrophobic Drugs: Solubilization of Paclitaxel |
title_sort | nonionic microemulsions as solubilizers of hydrophobic drugs: solubilization of paclitaxel |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5457098/ https://www.ncbi.nlm.nih.gov/pubmed/28773882 http://dx.doi.org/10.3390/ma9090761 |
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