Pulmonary Outcomes Following Specialized Respiratory Management for Acute Cervical Spinal Cord Injury: A Retrospective Analysis

STUDY DESIGN: Retrospective analysis. OBJECTIVES: To identify multivariate interactions of respiratory function that are sensitive to spinal cord injury level and pharmacological treatment to promote strategies that increases successful liberation from mechanical ventilation. SETTING: United States regional spinal cord injury (SCI) treatment center. METHODS: Retrospective chart review of patients consecutively admitted to Santa Clara Valley Medical Center (SCVMC) between May 2013 and December 2014 for ventilator weaning with C1-5 AIS A or B SCI, < 3 months from injury and who had a tracheostomy in place. A non-linear, categorical principal component analysis (NL-PCA) was performed to test the multivariate interaction of respiratory outcomes from patients (N=36) being weaned off ventilator support after acute SCI with (N=15) or without (N=21) theophylline treatment. RESULTS: 36 patients met inclusion criteria (2 C1, 5 C2, 11 C3, 14 C4, 4 C5). The NL-PCA returned 3 independent components that accounted for 95% of the variance in the dataset. Multivariate general linear models (GLM) hypothesis tests revealed a significant syndromic interaction between theophylline treatment and SCI level (Wilks’ Lambda, p=0.028, F(12,64)=2.116, η2=0.256, 1−β=0.838), with post-hoc testing demonstrating a significant interaction on PC1, explained by a positive correlation between improved forced vital capacity and time it took to reach 16 hours of ventilator free breathing. Thirty-three patients (92%) achieved 16 hours ventilator-free breathing (VFB), 30 (83%) achieved 24 hours VFB. CONCLUSIONS: We suspect that some portion of the high success rate of ventilator weaning may be attributable to theophylline use in higher cervical SCI; in addition to our aggressive regimen of high volume ventilation, medication optimization, and pulmonary toilet (positive pressure treatments and mechanical insufflation-exsufflation).