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Astragaloside IV alleviates heart failure via activating PPARα to switch glycolysis to fatty acid β-oxidation

In heart failure (HF), energy metabolism pathway in cardiac muscle changes from fatty acid β-oxidation to glycolysis. However, the exact mechanism is unknown. Sarcoendoplasmic reticulum Ca(2+)α ATPase (SERCA) expression is downregulated and mitochondrial function is reduced in HF, perhaps partly due...

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Detalles Bibliográficos
Autores principales:	Dong, Zhiwei, Zhao, Pei, Xu, Ming, Zhang, Chen, Guo, Wei, Chen, Huihua, Tian, Jing, Wei, Hongchang, lu, Rong, Cao, Tongtong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5457407/ https://www.ncbi.nlm.nih.gov/pubmed/28578382 http://dx.doi.org/10.1038/s41598-017-02360-5

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