A Class of Environmental and Endogenous Toxins Induces BRCA2 Haploinsufficiency and Genome Instability

Mutations truncating a single copy of the tumor suppressor, BRCA2, cause cancer susceptibility. In cells bearing such heterozygous mutations, we find that a cellular metabolite and ubiquitous environmental toxin, formaldehyde, stalls and destabilizes DNA replication forks, engendering structural chr...

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Detalles Bibliográficos
Autores principales: Tan, Shawn Lu Wen, Chadha, Saakshi, Liu, Yansheng, Gabasova, Evelina, Perera, David, Ahmed, Karim, Constantinou, Stephanie, Renaudin, Xavier, Lee, MiYoung, Aebersold, Ruedi, Venkitaraman, Ashok R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5457488/
https://www.ncbi.nlm.nih.gov/pubmed/28575672
http://dx.doi.org/10.1016/j.cell.2017.05.010

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