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Complementary information derived from CRISPR Cas9 mediated gene deletion and suppression

CRISPR-Cas9 provides the means to perform genome editing and facilitates loss-of-function screens. However, we and others demonstrated that expression of the Cas9 endonuclease induces a gene-independent response that correlates with the number of target sequences in the genome. An alternative approa...

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Detalles Bibliográficos
Autores principales:	Rosenbluh, Joseph, Xu, Han, Harrington, William, Gill, Stanley, Wang, Xiaoxing, Vazquez, Francisca, Root, David E., Tsherniak, Aviad, Hahn, William C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5457492/ https://www.ncbi.nlm.nih.gov/pubmed/28534478 http://dx.doi.org/10.1038/ncomms15403

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