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CDK4/6 inhibitor-SHR6390 exerts potent antitumor activity in esophageal squamous cell carcinoma by inhibiting phosphorylated Rb and inducing G1 cell cycle arrest

BACKGROUND: Cell cycle dysregulation is common in human malignancies, and CDK4/6 inhibitors targeting cell cycle have potential antitumor activity. SHR6390 is a novel small molecule inhibitor specifically targeting the CDK4/6 pathway. However, the role of SHR6390 in esophageal squamous cell carcinom...

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Detalles Bibliográficos
Autores principales:	Wang, Jiayuan, Li, Qingqing, Yuan, Jiajia, Wang, Jingyuan, Chen, Zuhua, Liu, Zhentao, Li, Zhongwu, Lai, Yumei, Gao, Jing, Shen, Lin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5457542/ https://www.ncbi.nlm.nih.gov/pubmed/28578693 http://dx.doi.org/10.1186/s12967-017-1231-7

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