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Efficient self-emulsification via cooling-heating cycles
In self-emulsification higher-energy micrometre and sub-micrometre oil droplets are spontaneously produced from larger ones and only a few such methods are known. They usually involve a one-time reduction in oil solubility in the continuous medium via changing temperature or solvents or a phase inve...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5457670/ https://www.ncbi.nlm.nih.gov/pubmed/28447603 http://dx.doi.org/10.1038/ncomms15012 |
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author | Tcholakova, Slavka Valkova, Zhulieta Cholakova, Diana Vinarov, Zahari Lesov, Ivan Denkov, Nikolai Smoukov, Stoyan K. |
author_facet | Tcholakova, Slavka Valkova, Zhulieta Cholakova, Diana Vinarov, Zahari Lesov, Ivan Denkov, Nikolai Smoukov, Stoyan K. |
author_sort | Tcholakova, Slavka |
collection | PubMed |
description | In self-emulsification higher-energy micrometre and sub-micrometre oil droplets are spontaneously produced from larger ones and only a few such methods are known. They usually involve a one-time reduction in oil solubility in the continuous medium via changing temperature or solvents or a phase inversion in which the preferred curvature of the interfacial surfactant layer changes its sign. Here we harness narrow-range temperature cycling to cause repeated breakup of droplets to higher-energy states. We describe three drop breakup mechanisms that lead the drops to burst spontaneously into thousands of smaller droplets. One of these mechanisms includes the remarkable phenomenon of lipid crystal dewetting from its own melt. The method works with various oil–surfactant combinations and has several important advantages. It enables low surfactant emulsion formulations with temperature-sensitive compounds, is scalable to industrial emulsification and applicable to fabricating particulate drug carriers with desired size and shape. |
format | Online Article Text |
id | pubmed-5457670 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-54576702017-06-08 Efficient self-emulsification via cooling-heating cycles Tcholakova, Slavka Valkova, Zhulieta Cholakova, Diana Vinarov, Zahari Lesov, Ivan Denkov, Nikolai Smoukov, Stoyan K. Nat Commun Article In self-emulsification higher-energy micrometre and sub-micrometre oil droplets are spontaneously produced from larger ones and only a few such methods are known. They usually involve a one-time reduction in oil solubility in the continuous medium via changing temperature or solvents or a phase inversion in which the preferred curvature of the interfacial surfactant layer changes its sign. Here we harness narrow-range temperature cycling to cause repeated breakup of droplets to higher-energy states. We describe three drop breakup mechanisms that lead the drops to burst spontaneously into thousands of smaller droplets. One of these mechanisms includes the remarkable phenomenon of lipid crystal dewetting from its own melt. The method works with various oil–surfactant combinations and has several important advantages. It enables low surfactant emulsion formulations with temperature-sensitive compounds, is scalable to industrial emulsification and applicable to fabricating particulate drug carriers with desired size and shape. Nature Publishing Group 2017-04-27 /pmc/articles/PMC5457670/ /pubmed/28447603 http://dx.doi.org/10.1038/ncomms15012 Text en Copyright © 2017, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Tcholakova, Slavka Valkova, Zhulieta Cholakova, Diana Vinarov, Zahari Lesov, Ivan Denkov, Nikolai Smoukov, Stoyan K. Efficient self-emulsification via cooling-heating cycles |
title | Efficient self-emulsification via cooling-heating cycles |
title_full | Efficient self-emulsification via cooling-heating cycles |
title_fullStr | Efficient self-emulsification via cooling-heating cycles |
title_full_unstemmed | Efficient self-emulsification via cooling-heating cycles |
title_short | Efficient self-emulsification via cooling-heating cycles |
title_sort | efficient self-emulsification via cooling-heating cycles |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5457670/ https://www.ncbi.nlm.nih.gov/pubmed/28447603 http://dx.doi.org/10.1038/ncomms15012 |
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