Cargando…

Global and local environmental changes as drivers of Buruli ulcer emergence

Many emerging infectious diseases are caused by generalist pathogens that infect and transmit via multiple host species with multiple dissemination routes, thus confounding the understanding of pathogen transmission pathways from wildlife reservoirs to humans. The emergence of these pathogens in hum...

Descripción completa

Detalles Bibliográficos
Autores principales: Combe, Marine, Velvin, Camilla Jensen, Morris, Aaron, Garchitorena, Andres, Carolan, Kevin, Sanhueza, Daniel, Roche, Benjamin, Couppié, Pierre, Guégan, Jean-François, Gozlan, Rodolphe Elie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5457673/
https://www.ncbi.nlm.nih.gov/pubmed/28442755
http://dx.doi.org/10.1038/emi.2017.7
_version_ 1783241592883118080
author Combe, Marine
Velvin, Camilla Jensen
Morris, Aaron
Garchitorena, Andres
Carolan, Kevin
Sanhueza, Daniel
Roche, Benjamin
Couppié, Pierre
Guégan, Jean-François
Gozlan, Rodolphe Elie
author_facet Combe, Marine
Velvin, Camilla Jensen
Morris, Aaron
Garchitorena, Andres
Carolan, Kevin
Sanhueza, Daniel
Roche, Benjamin
Couppié, Pierre
Guégan, Jean-François
Gozlan, Rodolphe Elie
author_sort Combe, Marine
collection PubMed
description Many emerging infectious diseases are caused by generalist pathogens that infect and transmit via multiple host species with multiple dissemination routes, thus confounding the understanding of pathogen transmission pathways from wildlife reservoirs to humans. The emergence of these pathogens in human populations has frequently been associated with global changes, such as socio-economic, climate or biodiversity modifications, by allowing generalist pathogens to invade and persist in new ecological niches, infect new host species, and thus change the nature of transmission pathways. Using the case of Buruli ulcer disease, we review how land-use changes, climatic patterns and biodiversity alterations contribute to disease emergence in many parts of the world. Here we clearly show that Mycobacterium ulcerans is an environmental pathogen characterized by multi-host transmission dynamics and that its infectious pathways to humans rely on the local effects of global environmental changes. We show that the interplay between habitat changes (for example, deforestation and agricultural land-use changes) and climatic patterns (for example, rainfall events), applied in a local context, can lead to abiotic environmental changes and functional changes in local biodiversity that favor the pathogen's prevalence in the environment and may explain disease emergence.
format Online
Article
Text
id pubmed-5457673
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-54576732017-06-07 Global and local environmental changes as drivers of Buruli ulcer emergence Combe, Marine Velvin, Camilla Jensen Morris, Aaron Garchitorena, Andres Carolan, Kevin Sanhueza, Daniel Roche, Benjamin Couppié, Pierre Guégan, Jean-François Gozlan, Rodolphe Elie Emerg Microbes Infect Review Many emerging infectious diseases are caused by generalist pathogens that infect and transmit via multiple host species with multiple dissemination routes, thus confounding the understanding of pathogen transmission pathways from wildlife reservoirs to humans. The emergence of these pathogens in human populations has frequently been associated with global changes, such as socio-economic, climate or biodiversity modifications, by allowing generalist pathogens to invade and persist in new ecological niches, infect new host species, and thus change the nature of transmission pathways. Using the case of Buruli ulcer disease, we review how land-use changes, climatic patterns and biodiversity alterations contribute to disease emergence in many parts of the world. Here we clearly show that Mycobacterium ulcerans is an environmental pathogen characterized by multi-host transmission dynamics and that its infectious pathways to humans rely on the local effects of global environmental changes. We show that the interplay between habitat changes (for example, deforestation and agricultural land-use changes) and climatic patterns (for example, rainfall events), applied in a local context, can lead to abiotic environmental changes and functional changes in local biodiversity that favor the pathogen's prevalence in the environment and may explain disease emergence. Nature Publishing Group 2017-04 2017-04-26 /pmc/articles/PMC5457673/ /pubmed/28442755 http://dx.doi.org/10.1038/emi.2017.7 Text en Copyright © 2017 The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Review
Combe, Marine
Velvin, Camilla Jensen
Morris, Aaron
Garchitorena, Andres
Carolan, Kevin
Sanhueza, Daniel
Roche, Benjamin
Couppié, Pierre
Guégan, Jean-François
Gozlan, Rodolphe Elie
Global and local environmental changes as drivers of Buruli ulcer emergence
title Global and local environmental changes as drivers of Buruli ulcer emergence
title_full Global and local environmental changes as drivers of Buruli ulcer emergence
title_fullStr Global and local environmental changes as drivers of Buruli ulcer emergence
title_full_unstemmed Global and local environmental changes as drivers of Buruli ulcer emergence
title_short Global and local environmental changes as drivers of Buruli ulcer emergence
title_sort global and local environmental changes as drivers of buruli ulcer emergence
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5457673/
https://www.ncbi.nlm.nih.gov/pubmed/28442755
http://dx.doi.org/10.1038/emi.2017.7
work_keys_str_mv AT combemarine globalandlocalenvironmentalchangesasdriversofburuliulceremergence
AT velvincamillajensen globalandlocalenvironmentalchangesasdriversofburuliulceremergence
AT morrisaaron globalandlocalenvironmentalchangesasdriversofburuliulceremergence
AT garchitorenaandres globalandlocalenvironmentalchangesasdriversofburuliulceremergence
AT carolankevin globalandlocalenvironmentalchangesasdriversofburuliulceremergence
AT sanhuezadaniel globalandlocalenvironmentalchangesasdriversofburuliulceremergence
AT rochebenjamin globalandlocalenvironmentalchangesasdriversofburuliulceremergence
AT couppiepierre globalandlocalenvironmentalchangesasdriversofburuliulceremergence
AT gueganjeanfrancois globalandlocalenvironmentalchangesasdriversofburuliulceremergence
AT gozlanrodolpheelie globalandlocalenvironmentalchangesasdriversofburuliulceremergence