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Global and local environmental changes as drivers of Buruli ulcer emergence
Many emerging infectious diseases are caused by generalist pathogens that infect and transmit via multiple host species with multiple dissemination routes, thus confounding the understanding of pathogen transmission pathways from wildlife reservoirs to humans. The emergence of these pathogens in hum...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5457673/ https://www.ncbi.nlm.nih.gov/pubmed/28442755 http://dx.doi.org/10.1038/emi.2017.7 |
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author | Combe, Marine Velvin, Camilla Jensen Morris, Aaron Garchitorena, Andres Carolan, Kevin Sanhueza, Daniel Roche, Benjamin Couppié, Pierre Guégan, Jean-François Gozlan, Rodolphe Elie |
author_facet | Combe, Marine Velvin, Camilla Jensen Morris, Aaron Garchitorena, Andres Carolan, Kevin Sanhueza, Daniel Roche, Benjamin Couppié, Pierre Guégan, Jean-François Gozlan, Rodolphe Elie |
author_sort | Combe, Marine |
collection | PubMed |
description | Many emerging infectious diseases are caused by generalist pathogens that infect and transmit via multiple host species with multiple dissemination routes, thus confounding the understanding of pathogen transmission pathways from wildlife reservoirs to humans. The emergence of these pathogens in human populations has frequently been associated with global changes, such as socio-economic, climate or biodiversity modifications, by allowing generalist pathogens to invade and persist in new ecological niches, infect new host species, and thus change the nature of transmission pathways. Using the case of Buruli ulcer disease, we review how land-use changes, climatic patterns and biodiversity alterations contribute to disease emergence in many parts of the world. Here we clearly show that Mycobacterium ulcerans is an environmental pathogen characterized by multi-host transmission dynamics and that its infectious pathways to humans rely on the local effects of global environmental changes. We show that the interplay between habitat changes (for example, deforestation and agricultural land-use changes) and climatic patterns (for example, rainfall events), applied in a local context, can lead to abiotic environmental changes and functional changes in local biodiversity that favor the pathogen's prevalence in the environment and may explain disease emergence. |
format | Online Article Text |
id | pubmed-5457673 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-54576732017-06-07 Global and local environmental changes as drivers of Buruli ulcer emergence Combe, Marine Velvin, Camilla Jensen Morris, Aaron Garchitorena, Andres Carolan, Kevin Sanhueza, Daniel Roche, Benjamin Couppié, Pierre Guégan, Jean-François Gozlan, Rodolphe Elie Emerg Microbes Infect Review Many emerging infectious diseases are caused by generalist pathogens that infect and transmit via multiple host species with multiple dissemination routes, thus confounding the understanding of pathogen transmission pathways from wildlife reservoirs to humans. The emergence of these pathogens in human populations has frequently been associated with global changes, such as socio-economic, climate or biodiversity modifications, by allowing generalist pathogens to invade and persist in new ecological niches, infect new host species, and thus change the nature of transmission pathways. Using the case of Buruli ulcer disease, we review how land-use changes, climatic patterns and biodiversity alterations contribute to disease emergence in many parts of the world. Here we clearly show that Mycobacterium ulcerans is an environmental pathogen characterized by multi-host transmission dynamics and that its infectious pathways to humans rely on the local effects of global environmental changes. We show that the interplay between habitat changes (for example, deforestation and agricultural land-use changes) and climatic patterns (for example, rainfall events), applied in a local context, can lead to abiotic environmental changes and functional changes in local biodiversity that favor the pathogen's prevalence in the environment and may explain disease emergence. Nature Publishing Group 2017-04 2017-04-26 /pmc/articles/PMC5457673/ /pubmed/28442755 http://dx.doi.org/10.1038/emi.2017.7 Text en Copyright © 2017 The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Review Combe, Marine Velvin, Camilla Jensen Morris, Aaron Garchitorena, Andres Carolan, Kevin Sanhueza, Daniel Roche, Benjamin Couppié, Pierre Guégan, Jean-François Gozlan, Rodolphe Elie Global and local environmental changes as drivers of Buruli ulcer emergence |
title | Global and local environmental changes as drivers of Buruli ulcer emergence |
title_full | Global and local environmental changes as drivers of Buruli ulcer emergence |
title_fullStr | Global and local environmental changes as drivers of Buruli ulcer emergence |
title_full_unstemmed | Global and local environmental changes as drivers of Buruli ulcer emergence |
title_short | Global and local environmental changes as drivers of Buruli ulcer emergence |
title_sort | global and local environmental changes as drivers of buruli ulcer emergence |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5457673/ https://www.ncbi.nlm.nih.gov/pubmed/28442755 http://dx.doi.org/10.1038/emi.2017.7 |
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