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Effects of Ramadan fasting on platelet reactivity in diabetic patients treated with clopidogrel
BACKGROUND: The effects of Ramadan fasting (RF) on clopidogrel antiplatelet inhibition were not previously investigated. The present study evaluated the influence of RF on platelet reactivity in patients with high cardiovascular risk (CVR) in particular those with type 2 diabetes mellitus (DM). METH...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5457725/ https://www.ncbi.nlm.nih.gov/pubmed/28588426 http://dx.doi.org/10.1186/s12959-017-0138-0 |
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author | Bouida, W. Baccouche, H. Sassi, M. Dridi, Z. Chakroun, T. Hellara, I. Boukef, R. Hassine, M. Added, F. Razgallah, R. Khochtali, I. Nouira, S. |
author_facet | Bouida, W. Baccouche, H. Sassi, M. Dridi, Z. Chakroun, T. Hellara, I. Boukef, R. Hassine, M. Added, F. Razgallah, R. Khochtali, I. Nouira, S. |
author_sort | Bouida, W. |
collection | PubMed |
description | BACKGROUND: The effects of Ramadan fasting (RF) on clopidogrel antiplatelet inhibition were not previously investigated. The present study evaluated the influence of RF on platelet reactivity in patients with high cardiovascular risk (CVR) in particular those with type 2 diabetes mellitus (DM). METHODS: A total of 98 stable patients with ≥2 CVR factors were recruited. All patients observed RF and were taking clopidogrel at a maintenance dose of 75 mg. Clinical findings and serum lipids data were recorded before Ramadan (Pre-R), at the last week of Ramadan (R) and 4 weeks after the end of Ramadan (Post-R). During each patient visit, nutrients intakes were calculated and platelet reactivity assessment using Verify Now P2Y12 assay was performed. RESULTS: In DM patients, the absolute PRU changes from baseline were +27 (p = 0.01) and +16 (p = 0.02) respectively at R and Post-R. In addition, there was a significant increase of glycemia and triglycerides levels with a significant decrease of high-density lipoprotein. In non DM patients there was no significant change in absolute PRU values and metabolic parameters. Clopidogrel resistance rate using 2 cut-off PRU values (235 and 208) did not change significantly in DM and non DM patients. CONCLUSIONS: RF significantly decreased platelet sensitivity to clopidogrel in DM patients during and after Ramadan. This effect is possibly related to an increase of glycemia and serum lipids levels induced by fasting. TRIAL REGISTRATION: Clinical Trials.gov NCT02720133. Registered 24 July 2014.Retrospectively registered. |
format | Online Article Text |
id | pubmed-5457725 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-54577252017-06-06 Effects of Ramadan fasting on platelet reactivity in diabetic patients treated with clopidogrel Bouida, W. Baccouche, H. Sassi, M. Dridi, Z. Chakroun, T. Hellara, I. Boukef, R. Hassine, M. Added, F. Razgallah, R. Khochtali, I. Nouira, S. Thromb J Research BACKGROUND: The effects of Ramadan fasting (RF) on clopidogrel antiplatelet inhibition were not previously investigated. The present study evaluated the influence of RF on platelet reactivity in patients with high cardiovascular risk (CVR) in particular those with type 2 diabetes mellitus (DM). METHODS: A total of 98 stable patients with ≥2 CVR factors were recruited. All patients observed RF and were taking clopidogrel at a maintenance dose of 75 mg. Clinical findings and serum lipids data were recorded before Ramadan (Pre-R), at the last week of Ramadan (R) and 4 weeks after the end of Ramadan (Post-R). During each patient visit, nutrients intakes were calculated and platelet reactivity assessment using Verify Now P2Y12 assay was performed. RESULTS: In DM patients, the absolute PRU changes from baseline were +27 (p = 0.01) and +16 (p = 0.02) respectively at R and Post-R. In addition, there was a significant increase of glycemia and triglycerides levels with a significant decrease of high-density lipoprotein. In non DM patients there was no significant change in absolute PRU values and metabolic parameters. Clopidogrel resistance rate using 2 cut-off PRU values (235 and 208) did not change significantly in DM and non DM patients. CONCLUSIONS: RF significantly decreased platelet sensitivity to clopidogrel in DM patients during and after Ramadan. This effect is possibly related to an increase of glycemia and serum lipids levels induced by fasting. TRIAL REGISTRATION: Clinical Trials.gov NCT02720133. Registered 24 July 2014.Retrospectively registered. BioMed Central 2017-06-02 /pmc/articles/PMC5457725/ /pubmed/28588426 http://dx.doi.org/10.1186/s12959-017-0138-0 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Bouida, W. Baccouche, H. Sassi, M. Dridi, Z. Chakroun, T. Hellara, I. Boukef, R. Hassine, M. Added, F. Razgallah, R. Khochtali, I. Nouira, S. Effects of Ramadan fasting on platelet reactivity in diabetic patients treated with clopidogrel |
title | Effects of Ramadan fasting on platelet reactivity in diabetic patients treated with clopidogrel |
title_full | Effects of Ramadan fasting on platelet reactivity in diabetic patients treated with clopidogrel |
title_fullStr | Effects of Ramadan fasting on platelet reactivity in diabetic patients treated with clopidogrel |
title_full_unstemmed | Effects of Ramadan fasting on platelet reactivity in diabetic patients treated with clopidogrel |
title_short | Effects of Ramadan fasting on platelet reactivity in diabetic patients treated with clopidogrel |
title_sort | effects of ramadan fasting on platelet reactivity in diabetic patients treated with clopidogrel |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5457725/ https://www.ncbi.nlm.nih.gov/pubmed/28588426 http://dx.doi.org/10.1186/s12959-017-0138-0 |
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