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Gender difference in the association between aminotransferase levels and hypertension in a Chinese elderly population

Few epidemiological studies have examined the association between serum aminotransferase levels and hypertension, and have yielded inconsistent results. A cross-sectional study was performed in a Chinese rural elderly population. A total of 2174 participants with normal range of aminotransferase lev...

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Autores principales: Wu, Lei, He, Yao, Jiang, Bin, Liu, Miao, Yang, Shanshan, Wang, Yiyan, Zeng, Jing, Yao, Yao, Wang, Jianhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5457891/
https://www.ncbi.nlm.nih.gov/pubmed/28538411
http://dx.doi.org/10.1097/MD.0000000000006996
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author Wu, Lei
He, Yao
Jiang, Bin
Liu, Miao
Yang, Shanshan
Wang, Yiyan
Zeng, Jing
Yao, Yao
Wang, Jianhua
author_facet Wu, Lei
He, Yao
Jiang, Bin
Liu, Miao
Yang, Shanshan
Wang, Yiyan
Zeng, Jing
Yao, Yao
Wang, Jianhua
author_sort Wu, Lei
collection PubMed
description Few epidemiological studies have examined the association between serum aminotransferase levels and hypertension, and have yielded inconsistent results. A cross-sectional study was performed in a Chinese rural elderly population. A total of 2174 participants with normal range of aminotransferase levels and without excessive drinking were included in the present study. Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels were measured on fasting morning serum samples using the Kinetic method. Hypertension was defined as systolic blood pressure ≥140 mm Hg and/or diastolic blood pressure ≥90 mm Hg and/or receiving treatment for hypertension. Multiple logistic regression was used to estimate the association between gender-specific aminotransferase levels and hypertension. Increased serum ALT but not AST level was positively associated with hypertension. After adjusting for potential confounding variables, the association of hypertension and ALT level was only significant in women: for each 1 IU/L elevation of ALT level, the adjusted odds ratio (OR), and corresponding 95% confidence interval (CI) of hypertension was 1.04 (1.01, 1.07); the ORs of hypertension increased across tertiles of ALT, and the ORs (95% CIs) were 1.00, 1.17 (0.85, 1.60), and 1.63 (1.15, 2.31 (P value for trend = .021). Furthermore, the association was only significant in central obesity women or nondrinking women. ALT level was significantly associated with hypertension only in women in a Chinese rural elderly population. Further studies are warranted to explore the possible gender-related association and to extend them to different populations.
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spelling pubmed-54578912017-06-09 Gender difference in the association between aminotransferase levels and hypertension in a Chinese elderly population Wu, Lei He, Yao Jiang, Bin Liu, Miao Yang, Shanshan Wang, Yiyan Zeng, Jing Yao, Yao Wang, Jianhua Medicine (Baltimore) 4400 Few epidemiological studies have examined the association between serum aminotransferase levels and hypertension, and have yielded inconsistent results. A cross-sectional study was performed in a Chinese rural elderly population. A total of 2174 participants with normal range of aminotransferase levels and without excessive drinking were included in the present study. Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels were measured on fasting morning serum samples using the Kinetic method. Hypertension was defined as systolic blood pressure ≥140 mm Hg and/or diastolic blood pressure ≥90 mm Hg and/or receiving treatment for hypertension. Multiple logistic regression was used to estimate the association between gender-specific aminotransferase levels and hypertension. Increased serum ALT but not AST level was positively associated with hypertension. After adjusting for potential confounding variables, the association of hypertension and ALT level was only significant in women: for each 1 IU/L elevation of ALT level, the adjusted odds ratio (OR), and corresponding 95% confidence interval (CI) of hypertension was 1.04 (1.01, 1.07); the ORs of hypertension increased across tertiles of ALT, and the ORs (95% CIs) were 1.00, 1.17 (0.85, 1.60), and 1.63 (1.15, 2.31 (P value for trend = .021). Furthermore, the association was only significant in central obesity women or nondrinking women. ALT level was significantly associated with hypertension only in women in a Chinese rural elderly population. Further studies are warranted to explore the possible gender-related association and to extend them to different populations. Wolters Kluwer Health 2017-05-26 /pmc/articles/PMC5457891/ /pubmed/28538411 http://dx.doi.org/10.1097/MD.0000000000006996 Text en Copyright © 2017 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0
spellingShingle 4400
Wu, Lei
He, Yao
Jiang, Bin
Liu, Miao
Yang, Shanshan
Wang, Yiyan
Zeng, Jing
Yao, Yao
Wang, Jianhua
Gender difference in the association between aminotransferase levels and hypertension in a Chinese elderly population
title Gender difference in the association between aminotransferase levels and hypertension in a Chinese elderly population
title_full Gender difference in the association between aminotransferase levels and hypertension in a Chinese elderly population
title_fullStr Gender difference in the association between aminotransferase levels and hypertension in a Chinese elderly population
title_full_unstemmed Gender difference in the association between aminotransferase levels and hypertension in a Chinese elderly population
title_short Gender difference in the association between aminotransferase levels and hypertension in a Chinese elderly population
title_sort gender difference in the association between aminotransferase levels and hypertension in a chinese elderly population
topic 4400
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5457891/
https://www.ncbi.nlm.nih.gov/pubmed/28538411
http://dx.doi.org/10.1097/MD.0000000000006996
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